"Commandeuring" Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism.

Barbara M A van Vugt-Lussenburg, Liliana Capinha, Jelle Reinen, Martijn Rooseboom, Michel Kranendonk, Rob C A Onderwater, Paul Jennings

Research output: Contribution to journalReview articlepeer-review

Abstract

The understanding of how exogenous chemicals (xenobiotics) are metabolized, distributed, and eliminated is critical to determine the impact of the chemical and its metabolites to the (human) organism. This is part of the research and educational discipline ADMET (absorption, distribution, metabolism, elimination, and toxicity). Here, we review the work of Jan Commandeur and colleagues who have not only made a significant impact in understanding of phase I and phase II metabolism of several important compounds but also contributed greatly to the development of experimental techniques for the study of xenobiotic metabolism. Jan Commandeur's work has covered a broad area of research, such as the development of online screening methodologies, the use of a combination of enzyme mutagenesis and molecular modeling for structure-activity relationship (SAR) studies, and the development of novel probe substrates. This work is the bedrock of current activities and brings the field closer to personalized (cohort-based) pharmacology, toxicology, and hazard/risk assessment.

Original languageEnglish
Pages (from-to)1184-1201
JournalChemical Research In Toxicology
Volume35
Issue number7
Early online date29 Jun 2022
DOIs
Publication statusPublished - 18 Jul 2022

Keywords

  • Anatomy
  • Metabolism
  • Peptides and proteins
  • Rodent models
  • Toxicity

Fingerprint

Dive into the research topics of '"Commandeuring" Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism.'. Together they form a unique fingerprint.

Cite this