TY - JOUR
T1 - "Commandeuring" Xenobiotic Metabolism
T2 - Advances in Understanding Xenobiotic Metabolism.
AU - van Vugt-Lussenburg, Barbara M A
AU - Capinha, Liliana
AU - Reinen, Jelle
AU - Rooseboom, Martijn
AU - Kranendonk, Michel
AU - Onderwater, Rob C A
AU - Jennings, Paul
PY - 2022/7/18
Y1 - 2022/7/18
N2 - The understanding of how exogenous chemicals (xenobiotics) are metabolized, distributed, and eliminated is critical to determine the impact of the chemical and its metabolites to the (human) organism. This is part of the research and educational discipline ADMET (absorption, distribution, metabolism, elimination, and toxicity). Here, we review the work of Jan Commandeur and colleagues who have not only made a significant impact in understanding of phase I and phase II metabolism of several important compounds but also contributed greatly to the development of experimental techniques for the study of xenobiotic metabolism. Jan Commandeur's work has covered a broad area of research, such as the development of online screening methodologies, the use of a combination of enzyme mutagenesis and molecular modeling for structure-activity relationship (SAR) studies, and the development of novel probe substrates. This work is the bedrock of current activities and brings the field closer to personalized (cohort-based) pharmacology, toxicology, and hazard/risk assessment.
AB - The understanding of how exogenous chemicals (xenobiotics) are metabolized, distributed, and eliminated is critical to determine the impact of the chemical and its metabolites to the (human) organism. This is part of the research and educational discipline ADMET (absorption, distribution, metabolism, elimination, and toxicity). Here, we review the work of Jan Commandeur and colleagues who have not only made a significant impact in understanding of phase I and phase II metabolism of several important compounds but also contributed greatly to the development of experimental techniques for the study of xenobiotic metabolism. Jan Commandeur's work has covered a broad area of research, such as the development of online screening methodologies, the use of a combination of enzyme mutagenesis and molecular modeling for structure-activity relationship (SAR) studies, and the development of novel probe substrates. This work is the bedrock of current activities and brings the field closer to personalized (cohort-based) pharmacology, toxicology, and hazard/risk assessment.
KW - Anatomy
KW - Metabolism
KW - Peptides and proteins
KW - Rodent models
KW - Toxicity
U2 - 10.1021/acs.chemrestox.2c00067
DO - 10.1021/acs.chemrestox.2c00067
M3 - Review article
C2 - 35768066
SN - 0893-228X
VL - 35
SP - 1184
EP - 1201
JO - Chemical Research In Toxicology
JF - Chemical Research In Toxicology
IS - 7
ER -