Abstract
Tuberculosis (TB) is an airborne infectious disease that is caused by Mycobacterium tuberculosis that is treatable and curable, however, it is still considered one of the top ten causes of death by infection worldwide. Its treatment includes a combination of various antibiotics that must be administered over several months, which could present different and severe adverse effects that compromise the compliance of the patients to the treatment and could contribute to the increase of the drug resistance to antituberculosis drugs. The World Health Organization has been establishing strategies to decrease the number of cases of TB infection worldwide, although an average of 1.3 million deaths was estimated in 2020, which makes it important to continue to investigate alternative and effective approaches for drug delivery in tuberculosis. Knowing that this chapter intends to focus on existing formulations for TB therapy, alternative therapies that have been investigated over the years, and exploring combination therapies for drug delivery in tuberculosis.
| Original language | English |
|---|---|
| Title of host publication | Combination Drug Delivery Approach as an Effective Therapy for Various Diseases |
| Publisher | Elsevier |
| Pages | 173-210 |
| Number of pages | 38 |
| ISBN (Electronic) | 978-032385873-1 |
| ISBN (Print) | 978-032385876-2 |
| DOIs | |
| Publication status | Published - 1 Jan 2022 |
Keywords
- anti-tuberculosis drugs
- drug delivery
- drug resistance
- green chemistry
- green solvents
- low temperature transition mixtures
- Tuberculosis infection
