TY - JOUR
T1 - Cobalt Ferrite Synthesized Using a Biogenic Sol–Gel Method for Biomedical Applications
AU - Gomes, Patrícia
AU - Costa, Bárbara
AU - Carvalho, João P. F.
AU - Soares, Paula I. P.
AU - Vieira, Tânia
AU - Henriques, Célia
AU - Valente, Manuel Almeida
AU - Teixeira, Sílvia Soreto
N1 - info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0037%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50025%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50025%2F2020/PT#
Publisher Copyright:
© 2023 by the authors.
PY - 2023/11/23
Y1 - 2023/11/23
N2 - Cancer is one of the leading causes of death worldwide. Conventional treatments such as surgery, chemotherapy, and radiotherapy have limitations and severe side effects. Magnetic hyperthermia (MH) is an alternative method that can be used alone or in conjunction with chemotherapy or radiotherapy to treat cancer. Cobalt ferrite particles were synthesized using an innovative biogenic sol–gel method with powder of coconut water (PCW). The obtained powders were subjected to heat treatments between 500 °C and 1100 °C. Subsequently, they were characterized by thermal, structural, magnetic, and cytotoxic analyses to assess their suitability for MH applications. Through X-ray diffraction and Raman spectroscopy, it was possible to confirm the presence of the pure phase of CoFe2O4 in the sample treated at 1100 °C, exhibiting a saturation magnetization of 84 emu/g at 300 K and an average grain size of 542 nm. Furthermore, the sample treated at 1100 °C showed a specific absorption rate (SAR) of 3.91 W/g, and at concentrations equal to or below 5 mg/mL, is non-cytotoxic, being the most suitable for biomedical applications.
AB - Cancer is one of the leading causes of death worldwide. Conventional treatments such as surgery, chemotherapy, and radiotherapy have limitations and severe side effects. Magnetic hyperthermia (MH) is an alternative method that can be used alone or in conjunction with chemotherapy or radiotherapy to treat cancer. Cobalt ferrite particles were synthesized using an innovative biogenic sol–gel method with powder of coconut water (PCW). The obtained powders were subjected to heat treatments between 500 °C and 1100 °C. Subsequently, they were characterized by thermal, structural, magnetic, and cytotoxic analyses to assess their suitability for MH applications. Through X-ray diffraction and Raman spectroscopy, it was possible to confirm the presence of the pure phase of CoFe2O4 in the sample treated at 1100 °C, exhibiting a saturation magnetization of 84 emu/g at 300 K and an average grain size of 542 nm. Furthermore, the sample treated at 1100 °C showed a specific absorption rate (SAR) of 3.91 W/g, and at concentrations equal to or below 5 mg/mL, is non-cytotoxic, being the most suitable for biomedical applications.
KW - cancer
KW - cobalt ferrite
KW - magnetic hyperthermia
KW - magnetic nanoparticles
KW - sol–gel
UR - http://www.scopus.com/inward/record.url?scp=85179343451&partnerID=8YFLogxK
U2 - 10.3390/molecules28237737
DO - 10.3390/molecules28237737
M3 - Article
C2 - 38067467
AN - SCOPUS:85179343451
SN - 1420-3049
VL - 28
JO - Molecules
JF - Molecules
IS - 23
M1 - 7737
ER -