TY - JOUR
T1 - Cobalt and Zinc Compounds Bearing 1,10-Phenanthroline-5,6-dione or 1,3,5-Triaza-7-phosphaadamantaneDerivatives
T2 - Synthesis, Characterization, Cytotoxicity,and Cell Selectivity Studies
AU - Silva, Telma F. S.
AU - Smoleński, Piotr
AU - Martins, Luísa M. D. R. S.
AU - Guedes da Silva, M. Fátima C.
AU - Fernandes, Alexandra R.
AU - Luís, Daniel
AU - Silva, Ana
AU - Santos, Susana
AU - Borralho, Pedro M.
AU - Rodrigues, Cecília M. P.
AU - Pombeiro, Armando J. L.
N1 - Sem pdf
PY - 2013/7
Y1 - 2013/7
N2 - The compounds [mPTA][CoCl4] (1, mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation), [CoCl(H2O)(DION)2]-[BF4](2,DION=1,10-phenanthroline-5,6-dione),[Zn(DION)2]-Cl2 (3) and [ZnCl(κO-PTA=O)(DION)][BF4] (4) were synthesizedby reaction of CoCl2 with [mPTA]I or DION and ZnCl216 with DION or 1,3,5-triaza-7-phosphaadamantane-7-oxide(PTA=O) and DION, respectively. All complexes are watersoluble and have been characterized by IR, far-IR, 1H, 13C and 31P{1H} NMR spectroscopy, ESI-MS, elemental analysesand single-crystal X-ray diffraction structural analysis (for 1).They were screened against the human tumour cell lines 21HCT116, HepG2 and MCF7. Complexes 2 and 3 exhibit thehighest in vitro cytotoxicity and show lower cytotoxic activitiesin normal human fibroblast cell line than in HCT116 tumourcell line, which demonstrates their slight specificity forthis type of tumour cell.
AB - The compounds [mPTA][CoCl4] (1, mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation), [CoCl(H2O)(DION)2]-[BF4](2,DION=1,10-phenanthroline-5,6-dione),[Zn(DION)2]-Cl2 (3) and [ZnCl(κO-PTA=O)(DION)][BF4] (4) were synthesizedby reaction of CoCl2 with [mPTA]I or DION and ZnCl216 with DION or 1,3,5-triaza-7-phosphaadamantane-7-oxide(PTA=O) and DION, respectively. All complexes are watersoluble and have been characterized by IR, far-IR, 1H, 13C and 31P{1H} NMR spectroscopy, ESI-MS, elemental analysesand single-crystal X-ray diffraction structural analysis (for 1).They were screened against the human tumour cell lines 21HCT116, HepG2 and MCF7. Complexes 2 and 3 exhibit thehighest in vitro cytotoxicity and show lower cytotoxic activitiesin normal human fibroblast cell line than in HCT116 tumourcell line, which demonstrates their slight specificity forthis type of tumour cell.
U2 - 10.1002/ejic.201300197
DO - 10.1002/ejic.201300197
M3 - Article
SN - 1434-1948
VL - 2013
SP - 3651
EP - 3658
JO - European Journal of Inorganic Chemistry
JF - European Journal of Inorganic Chemistry
IS - 21
ER -