TY - CHAP
T1 - Clostridioides difficile Sporulation
AU - Serrano, Mónica
AU - Martins, Diogo
AU - Henriques, Adriano O.
N1 - Funding Information:
Acknowledgements This work was also supported by “Fundação para a Ciência e a Tecnologia” (FCT), Portugal through grants PTDC/BIA-MIC/32542/2017 to AOH and PTDC/BIA-MIC/29293/2017 to MS, by the European Union Marie Sklodowska Curie Innovative Training Networks (contract number 642068) to AOH. The work was also funded by project LISBOA-01-0145-FEDER-007660 (“Microbiologia Molecular, Estrutural e Celular”) funded by FEDER funds through COMPETE2020—“-Programa Operacional Competitividade e Internacionalização”, and by project PPBI—Portuguese Platform of BioImaging (PPBI-POCI-01-0145-FEDER-022122) co-funded by national funds from OE—“-Orçamento de Estado” and by European funds from FEDER—“Fundo Europeu de Desenvolvimento Regional”. DM is the recipient of a PhD fellowship (PD/BD/143148/2019) within the scope of the PhD programme INTERFACE funded by FCT.
Publisher Copyright:
© 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2024/1/5
Y1 - 2024/1/5
N2 - Some members of the Firmicutes phylum, including many members of the human gut microbiota, are able to differentiate a dormant and highly resistant cell type, the endospore (hereinafter spore for simplicity). Spore-formers can colonize virtually any habitat and, because of their resistance to a wide variety of physical and chemical insults, spores can remain viable in the environment for long periods of time. In the anaerobic enteric pathogen Clostridioides difficile the aetiologic agent is the oxygen-resistant spore, while the toxins produced by actively growing cells are the main cause of the disease symptoms. Here, we review the regulatory circuits that govern entry into sporulation. We also cover the role of spores in the infectious cycle of C. difficile in relation to spore structure and function and the main control points along spore morphogenesis.
AB - Some members of the Firmicutes phylum, including many members of the human gut microbiota, are able to differentiate a dormant and highly resistant cell type, the endospore (hereinafter spore for simplicity). Spore-formers can colonize virtually any habitat and, because of their resistance to a wide variety of physical and chemical insults, spores can remain viable in the environment for long periods of time. In the anaerobic enteric pathogen Clostridioides difficile the aetiologic agent is the oxygen-resistant spore, while the toxins produced by actively growing cells are the main cause of the disease symptoms. Here, we review the regulatory circuits that govern entry into sporulation. We also cover the role of spores in the infectious cycle of C. difficile in relation to spore structure and function and the main control points along spore morphogenesis.
KW - Exosporium
KW - Intercellular communication
KW - Morphological checkpoints
KW - Spore coat
KW - Sporulation
UR - http://www.scopus.com/inward/record.url?scp=85181765541&partnerID=8YFLogxK
U2 - 10.1007/978-3-031-42108-2_13
DO - 10.1007/978-3-031-42108-2_13
M3 - Chapter
C2 - 38175480
AN - SCOPUS:85181765541
T3 - Advances in Experimental Medicine and Biology
SP - 273
EP - 314
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -
