Clinical and laboratory profile of Zika virus infection in dengue suspected patients

A case series

Cássia Fernanda Estofolete, Ana Carolina Bernardes Terzian, Ricardo Parreira, Aida Esteves, Lucas Hardman, Gilmar Valdir Greque, Paula Rahal, Maurício Lacerda Nogueira

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: The Zika virus (ZIKV) is an emerging arthropod-borne virus related to the dengue virus (DENV), and shows a similar clinical profile as other arboviral diseases, such as dengue and chikungunya virus (CHIKV). Historically, ZIKV has been associated with sporadic cases of human infection, but is now responsible for outbreaks worldwide. In Brazil, cases have been reported since 2015, with some cases causing severe disease. Objective: To identify clinical symptoms of Zika in patients in Dengue suspected patients. Study design: Description of a series of cases, wherein we analyzed 100 clinical samples collected from patients who exhibited acute febrile disease for ≤5 days, from January to February 2016. Results: In this study, we report 13 cases of ZIKV infection in adults presenting dengue-like symptoms in a DENV endemic area. All patients presented with fever, with myalgia being the second most frequently observed symptom. Two patients had rashes, but none of them had conjunctivitis. Other less frequent manifestations included headache, arthralgia, diarrhea, and nausea. Conclusion: The co-circulation of ZIKV and DENV is a serious public health concern, since it represents both a clinical and diagnostic challenge in endemic areas, as well as in the field of travel medicine.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalJournal Of Clinical Virology
Volume81
DOIs
Publication statusPublished - 1 Aug 2016

Fingerprint

Dengue
Dengue Virus
Fever
Travel Medicine
Chikungunya virus
Arboviruses
Conjunctivitis
Myalgia
Arthralgia
Acute Disease
Exanthema
Nausea
Disease Outbreaks
Brazil
Headache
Diarrhea
Public Health
Zika Virus Infection
Infection
Zika Virus

Keywords

  • Arbovirus
  • Chikungunya virus
  • Dengue virus
  • NS1
  • Zika virus

Cite this

Fernanda Estofolete, Cássia ; Terzian, Ana Carolina Bernardes ; Parreira, Ricardo ; Esteves, Aida ; Hardman, Lucas ; Greque, Gilmar Valdir ; Rahal, Paula ; Nogueira, Maurício Lacerda. / Clinical and laboratory profile of Zika virus infection in dengue suspected patients : A case series. In: Journal Of Clinical Virology. 2016 ; Vol. 81. pp. 25-30.
@article{fe7f4803573e403da5dc4630a82ffefb,
title = "Clinical and laboratory profile of Zika virus infection in dengue suspected patients: A case series",
abstract = "Background: The Zika virus (ZIKV) is an emerging arthropod-borne virus related to the dengue virus (DENV), and shows a similar clinical profile as other arboviral diseases, such as dengue and chikungunya virus (CHIKV). Historically, ZIKV has been associated with sporadic cases of human infection, but is now responsible for outbreaks worldwide. In Brazil, cases have been reported since 2015, with some cases causing severe disease. Objective: To identify clinical symptoms of Zika in patients in Dengue suspected patients. Study design: Description of a series of cases, wherein we analyzed 100 clinical samples collected from patients who exhibited acute febrile disease for ≤5 days, from January to February 2016. Results: In this study, we report 13 cases of ZIKV infection in adults presenting dengue-like symptoms in a DENV endemic area. All patients presented with fever, with myalgia being the second most frequently observed symptom. Two patients had rashes, but none of them had conjunctivitis. Other less frequent manifestations included headache, arthralgia, diarrhea, and nausea. Conclusion: The co-circulation of ZIKV and DENV is a serious public health concern, since it represents both a clinical and diagnostic challenge in endemic areas, as well as in the field of travel medicine.",
keywords = "Arbovirus, Chikungunya virus, Dengue virus, NS1, Zika virus",
author = "{Fernanda Estofolete}, C{\'a}ssia and Terzian, {Ana Carolina Bernardes} and Ricardo Parreira and Aida Esteves and Lucas Hardman and Greque, {Gilmar Valdir} and Paula Rahal and Nogueira, {Maur{\'i}cio Lacerda}",
year = "2016",
month = "8",
day = "1",
doi = "10.1016/j.jcv.2016.05.012",
language = "English",
volume = "81",
pages = "25--30",
journal = "Journal Of Clinical Virology",
issn = "1386-6532",
publisher = "Elsevier Science B.V., Amsterdam.",

}

Clinical and laboratory profile of Zika virus infection in dengue suspected patients : A case series. / Fernanda Estofolete, Cássia; Terzian, Ana Carolina Bernardes; Parreira, Ricardo; Esteves, Aida; Hardman, Lucas; Greque, Gilmar Valdir; Rahal, Paula; Nogueira, Maurício Lacerda.

In: Journal Of Clinical Virology, Vol. 81, 01.08.2016, p. 25-30.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical and laboratory profile of Zika virus infection in dengue suspected patients

T2 - A case series

AU - Fernanda Estofolete, Cássia

AU - Terzian, Ana Carolina Bernardes

AU - Parreira, Ricardo

AU - Esteves, Aida

AU - Hardman, Lucas

AU - Greque, Gilmar Valdir

AU - Rahal, Paula

AU - Nogueira, Maurício Lacerda

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Background: The Zika virus (ZIKV) is an emerging arthropod-borne virus related to the dengue virus (DENV), and shows a similar clinical profile as other arboviral diseases, such as dengue and chikungunya virus (CHIKV). Historically, ZIKV has been associated with sporadic cases of human infection, but is now responsible for outbreaks worldwide. In Brazil, cases have been reported since 2015, with some cases causing severe disease. Objective: To identify clinical symptoms of Zika in patients in Dengue suspected patients. Study design: Description of a series of cases, wherein we analyzed 100 clinical samples collected from patients who exhibited acute febrile disease for ≤5 days, from January to February 2016. Results: In this study, we report 13 cases of ZIKV infection in adults presenting dengue-like symptoms in a DENV endemic area. All patients presented with fever, with myalgia being the second most frequently observed symptom. Two patients had rashes, but none of them had conjunctivitis. Other less frequent manifestations included headache, arthralgia, diarrhea, and nausea. Conclusion: The co-circulation of ZIKV and DENV is a serious public health concern, since it represents both a clinical and diagnostic challenge in endemic areas, as well as in the field of travel medicine.

AB - Background: The Zika virus (ZIKV) is an emerging arthropod-borne virus related to the dengue virus (DENV), and shows a similar clinical profile as other arboviral diseases, such as dengue and chikungunya virus (CHIKV). Historically, ZIKV has been associated with sporadic cases of human infection, but is now responsible for outbreaks worldwide. In Brazil, cases have been reported since 2015, with some cases causing severe disease. Objective: To identify clinical symptoms of Zika in patients in Dengue suspected patients. Study design: Description of a series of cases, wherein we analyzed 100 clinical samples collected from patients who exhibited acute febrile disease for ≤5 days, from January to February 2016. Results: In this study, we report 13 cases of ZIKV infection in adults presenting dengue-like symptoms in a DENV endemic area. All patients presented with fever, with myalgia being the second most frequently observed symptom. Two patients had rashes, but none of them had conjunctivitis. Other less frequent manifestations included headache, arthralgia, diarrhea, and nausea. Conclusion: The co-circulation of ZIKV and DENV is a serious public health concern, since it represents both a clinical and diagnostic challenge in endemic areas, as well as in the field of travel medicine.

KW - Arbovirus

KW - Chikungunya virus

KW - Dengue virus

KW - NS1

KW - Zika virus

UR - http://www.scopus.com/inward/record.url?scp=84973443291&partnerID=8YFLogxK

U2 - 10.1016/j.jcv.2016.05.012

DO - 10.1016/j.jcv.2016.05.012

M3 - Article

VL - 81

SP - 25

EP - 30

JO - Journal Of Clinical Virology

JF - Journal Of Clinical Virology

SN - 1386-6532

ER -