Chronodisruption and Ambulatory Circadian Monitoring in Cancer Patients: Beyond the Body Clock

Pedro F. Almaida-Pagan, María Torrente, Manuel Campos, Mariano Provencio, Juan Antonio Madrid, Fabio Franco, Beatriz Rodríguez Morilla, Blanca Cantos, Pedro A. Sousa, María José Martínez Madrid, João Pimentao, María Ángeles Rol

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Purpose of Review: Circadian rhythms impose daily rhythms a remarkable variety of metabolic and physiological functions, such as cell proliferation, inflammation, and DNA damage response. Accumulating epidemiological and genetic evidence indicates that circadian rhythms’ disruption may be linked to cancer. The integration of circadian biology into cancer research may offer new options for increasing cancer treatment effectiveness and would encompass the prevention, diagnosis, and treatment of this disease. Recent Findings: In recent years, there has been a significant development and use of multi-modal sensors to monitor physical activity, sleep, and circadian rhythms, allowing, for the very first time, scaling accurate sleep monitoring to epidemiological research linking sleep patterns to disease, and wellness applications providing new potential applications. Summary: This review highlights the role of circadian clock in tumorigenesis, cancer hallmarks and introduces the state-of-the-art in sleep-monitoring technologies, discussing the eventual application of insights in clinical settings and cancer research.

Original languageEnglish
Pages (from-to)135-149
JournalCurrent Oncology Reports
Issue number2
Publication statusPublished - Feb 2022


  • Ambulatory circadian monitoring
  • Cancer patients
  • Chronodisruption
  • Circadian rhythms
  • Multi-modal sensors
  • Tumorigenesis


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