Hipocalcemia Crónica por Anticorpos Anti-Recetor do Cálcio

Translated title of the contribution: Chronic Hypocalcemia due to Anti-Calcium Sensing Receptor Antibodies

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Abstract

Introduction: Hypoparathyroidism is an entity associated with hypocalcemia, more frequently a consequence of neck surgery. An autoimmune etiology is rare and its diagnosis difficult to establish. Clinical report: 52 year-old woman, with irrelevant past medical history and no significant familial conditions, referred because of hypocalcemia and basal ganglia calcifications, detected in the course of investigation of myalgias. Besides hypocalcemia (4.6 mg/dL), hyperphosphatemia (8.7 mg/dL), undetectable parathyroid hormone and low urinary calcium, phosphorus and magnesium were present. Molecular analysis of CaSR gene excluded germinal mutations. Anti-calcium sensing receptor antibodies (anti-CaSR) were present. The patient is asymptomatic and normocalcemic under treatment with calcium and vitamin D. Discussion: Although rare, hypocalcemia due to anti-CaSR hypoparathyroidism must be considered in the absence of previous neck surgery, hypocalcemic drugs, familial history or phenotype suggesting a genetic disorder. Low or undetectable parathyroid hormone excludes pseudohypoparathyroidism and anti-CaSR positivity establishes the diagnosis.
Translated title of the contributionChronic Hypocalcemia due to Anti-Calcium Sensing Receptor Antibodies
Original languagePortuguese
Pages (from-to)399-402
Number of pages3
JournalActa medica portuguesa
Volume27
Issue number3
Publication statusPublished - May 2014

Keywords

  • Hypocalcemia
  • Hypoparathyroidism
  • Autoantibodies
  • Receptors
  • Calcium-Sensing

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