Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats

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Abstract

We tested the hypothesis that long-term caffeine intake prevents the development of insulin resistance and hypertension in two pathological animal models: the high-fat (HF) and the high-sucrose (HSu.) diet rat. We used six groups of animals: control; caffeine-treated (Gaff; 1 g/l in drinking water during 15 d); HF; caffeine-treated HF (HFCaff); HSu; caffeine-treated HSu (HSuCaff). Insulin sensitivity was assessed using the insulin tolerance test. Blood pressure, weight gain, visceral fat, hepatic glutathione, plasma caffeine, insulin and NO, and serum NEFA and catecholamines were measured. Caffeine reversed insulin resistance and hypertension induced by both the HF and HSu diets. In the HF-fed animals caffeine treatment restored fasting insulin levels to control values and reversed increased weight gain and visceral fat mass. In the HSu group, caffeine reversed fasting hyperglycaemia and restored NEFA to control values. There were no changes either in plasma NO or in hepatic glutathione levels. In contrast, caffeine totally prevented the increase in serum catecholamines induced by HF and HSu diets. To test the hypothesis that inhibition of the sympathetic nervous system prevents the development of diet-induced insulin resistance we administered carvedilol, an antagonist of beta 1, beta 2 and also alpha 1 adrenoceptors, to HF and HSu rats. Carvedilol treatment fully prevented diet-induced insulin resistance and hypertension, mimicking the effect of caffeine. We concluded that long-term caffeine intake prevented the development of insulin resistance and hypertension in and HSu models and that this effect was related to a decrease in circulating catecholamines.
Original languageEnglish
Pages (from-to)86-95
Number of pages10
JournalBritish Journal Of Nutrition
Volume107
Issue number1
DOIs
Publication statusPublished - Jan 2012

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Caffeine
Catecholamines
Insulin Resistance
Diet
Hypertension
High Fat Diet
Fats
Intra-Abdominal Fat
Insulin
Nonesterified Fatty Acids
Weight Gain
Glutathione
Fasting
Liver
Sympathetic Nervous System
Serum
Drinking Water
Hyperglycemia
Adrenergic Receptors
Sucrose

Keywords

  • Caffeine
  • Insulin resistance
  • Hypertension
  • Catecholamines

Cite this

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title = "Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats",
abstract = "We tested the hypothesis that long-term caffeine intake prevents the development of insulin resistance and hypertension in two pathological animal models: the high-fat (HF) and the high-sucrose (HSu.) diet rat. We used six groups of animals: control; caffeine-treated (Gaff; 1 g/l in drinking water during 15 d); HF; caffeine-treated HF (HFCaff); HSu; caffeine-treated HSu (HSuCaff). Insulin sensitivity was assessed using the insulin tolerance test. Blood pressure, weight gain, visceral fat, hepatic glutathione, plasma caffeine, insulin and NO, and serum NEFA and catecholamines were measured. Caffeine reversed insulin resistance and hypertension induced by both the HF and HSu diets. In the HF-fed animals caffeine treatment restored fasting insulin levels to control values and reversed increased weight gain and visceral fat mass. In the HSu group, caffeine reversed fasting hyperglycaemia and restored NEFA to control values. There were no changes either in plasma NO or in hepatic glutathione levels. In contrast, caffeine totally prevented the increase in serum catecholamines induced by HF and HSu diets. To test the hypothesis that inhibition of the sympathetic nervous system prevents the development of diet-induced insulin resistance we administered carvedilol, an antagonist of beta 1, beta 2 and also alpha 1 adrenoceptors, to HF and HSu rats. Carvedilol treatment fully prevented diet-induced insulin resistance and hypertension, mimicking the effect of caffeine. We concluded that long-term caffeine intake prevented the development of insulin resistance and hypertension in and HSu models and that this effect was related to a decrease in circulating catecholamines.",
keywords = "Hypertension, BLOOD-PRESSURE RESPONSE, Insulin resistance, MUSCLE, SENSITIVITY, WEIGHT, Catecholamines, ADENOSINE, GLUCOSE-HOMEOSTASIS, MEN, US WOMEN, COFFEE CONSUMPTION, A(2B) RECEPTORS, Caffeine, Caffeine, Insulin resistance, Hypertension, Catecholamines",
author = "Silvia Conde and Silva, {Tiago Nunes da} and Constancio Gonzalez and Carmo, {Miguel Mota} and Monteiro, {Em{\'i}lia C} and Guarino, {Maria P}",
year = "2012",
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language = "English",
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TY - JOUR

T1 - Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats

AU - Conde, Silvia

AU - Silva, Tiago Nunes da

AU - Gonzalez, Constancio

AU - Carmo, Miguel Mota

AU - Monteiro, Emília C

AU - Guarino, Maria P

PY - 2012/1

Y1 - 2012/1

N2 - We tested the hypothesis that long-term caffeine intake prevents the development of insulin resistance and hypertension in two pathological animal models: the high-fat (HF) and the high-sucrose (HSu.) diet rat. We used six groups of animals: control; caffeine-treated (Gaff; 1 g/l in drinking water during 15 d); HF; caffeine-treated HF (HFCaff); HSu; caffeine-treated HSu (HSuCaff). Insulin sensitivity was assessed using the insulin tolerance test. Blood pressure, weight gain, visceral fat, hepatic glutathione, plasma caffeine, insulin and NO, and serum NEFA and catecholamines were measured. Caffeine reversed insulin resistance and hypertension induced by both the HF and HSu diets. In the HF-fed animals caffeine treatment restored fasting insulin levels to control values and reversed increased weight gain and visceral fat mass. In the HSu group, caffeine reversed fasting hyperglycaemia and restored NEFA to control values. There were no changes either in plasma NO or in hepatic glutathione levels. In contrast, caffeine totally prevented the increase in serum catecholamines induced by HF and HSu diets. To test the hypothesis that inhibition of the sympathetic nervous system prevents the development of diet-induced insulin resistance we administered carvedilol, an antagonist of beta 1, beta 2 and also alpha 1 adrenoceptors, to HF and HSu rats. Carvedilol treatment fully prevented diet-induced insulin resistance and hypertension, mimicking the effect of caffeine. We concluded that long-term caffeine intake prevented the development of insulin resistance and hypertension in and HSu models and that this effect was related to a decrease in circulating catecholamines.

AB - We tested the hypothesis that long-term caffeine intake prevents the development of insulin resistance and hypertension in two pathological animal models: the high-fat (HF) and the high-sucrose (HSu.) diet rat. We used six groups of animals: control; caffeine-treated (Gaff; 1 g/l in drinking water during 15 d); HF; caffeine-treated HF (HFCaff); HSu; caffeine-treated HSu (HSuCaff). Insulin sensitivity was assessed using the insulin tolerance test. Blood pressure, weight gain, visceral fat, hepatic glutathione, plasma caffeine, insulin and NO, and serum NEFA and catecholamines were measured. Caffeine reversed insulin resistance and hypertension induced by both the HF and HSu diets. In the HF-fed animals caffeine treatment restored fasting insulin levels to control values and reversed increased weight gain and visceral fat mass. In the HSu group, caffeine reversed fasting hyperglycaemia and restored NEFA to control values. There were no changes either in plasma NO or in hepatic glutathione levels. In contrast, caffeine totally prevented the increase in serum catecholamines induced by HF and HSu diets. To test the hypothesis that inhibition of the sympathetic nervous system prevents the development of diet-induced insulin resistance we administered carvedilol, an antagonist of beta 1, beta 2 and also alpha 1 adrenoceptors, to HF and HSu rats. Carvedilol treatment fully prevented diet-induced insulin resistance and hypertension, mimicking the effect of caffeine. We concluded that long-term caffeine intake prevented the development of insulin resistance and hypertension in and HSu models and that this effect was related to a decrease in circulating catecholamines.

KW - Hypertension

KW - BLOOD-PRESSURE RESPONSE

KW - Insulin resistance

KW - MUSCLE

KW - SENSITIVITY

KW - WEIGHT

KW - Catecholamines

KW - ADENOSINE

KW - GLUCOSE-HOMEOSTASIS

KW - MEN

KW - US WOMEN

KW - COFFEE CONSUMPTION

KW - A(2B) RECEPTORS

KW - Caffeine

KW - Caffeine

KW - Insulin resistance

KW - Hypertension

KW - Catecholamines

U2 - 10.1017/S0007114511002406

DO - 10.1017/S0007114511002406

M3 - Article

VL - 107

SP - 86

EP - 95

JO - British Journal Of Nutrition

JF - British Journal Of Nutrition

SN - 0007-1145

IS - 1

ER -