TY - JOUR
T1 - Choroidal thinning
T2 - Alzheimer's disease and aging
AU - Cunha, João Paulo
AU - Proença, Rita
AU - Dias-Santos, Arnaldo
AU - Melancia, Diana
AU - Almeida, Rita
AU - Águas, Helena
AU - Santos, Bruno Oliveira
AU - Alves, Marta
AU - Ferreira, Joana
AU - Papoila, Ana Luísa
AU - Louro, Carlota
AU - Castanheira-Dinis, António
PY - 2017
Y1 - 2017
N2 - Introduction The purpose of this study was to measure and to compare macular choroidal thickness (CT) between patients with mild Alzheimer's disease (AD), patients without AD, and elderly patients. Methods CT was measured manually in 13 locations at 500-μm intervals of a horizontal and a vertical section from the fovea. Linear regression models were used to analyze the data. Results Fifty patients with a diagnosis of mild AD (73.1 years), 152 patients without AD (71.03 years), and 50 elderly without AD (82.14 years) were included. In the AD patients, CT was significantly thinner in all 13 locations (P < .001—comparing with age-match group), and comparing with the elderly group, a more pronounced difference was found in two locations temporal to the fovea. Discussion Patients with AD showed a significant choroidal thinning even when compared with elderly subjects. The reduction of CT may aid in the diagnoses of AD, probably reflecting the importance of vascular factors in their pathogenesis.
AB - Introduction The purpose of this study was to measure and to compare macular choroidal thickness (CT) between patients with mild Alzheimer's disease (AD), patients without AD, and elderly patients. Methods CT was measured manually in 13 locations at 500-μm intervals of a horizontal and a vertical section from the fovea. Linear regression models were used to analyze the data. Results Fifty patients with a diagnosis of mild AD (73.1 years), 152 patients without AD (71.03 years), and 50 elderly without AD (82.14 years) were included. In the AD patients, CT was significantly thinner in all 13 locations (P < .001—comparing with age-match group), and comparing with the elderly group, a more pronounced difference was found in two locations temporal to the fovea. Discussion Patients with AD showed a significant choroidal thinning even when compared with elderly subjects. The reduction of CT may aid in the diagnoses of AD, probably reflecting the importance of vascular factors in their pathogenesis.
KW - Aging
KW - Alzheimer's choroidopathy
KW - Alzheimer's disease
KW - Choroidal thickness
KW - Enhanced depth imaging
KW - Spectral-domain optical coherence tomography
UR - http://www.scopus.com/inward/record.url?scp=85017291672&partnerID=8YFLogxK
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390660/
U2 - 10.1016/j.dadm.2017.03.004
DO - 10.1016/j.dadm.2017.03.004
M3 - Article
C2 - 28435851
AN - SCOPUS:85017291672
VL - 8
SP - 11
EP - 17
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
SN - 2352-8729
ER -
