TY - JOUR
T1 - Chlorpromazine has intracellular killing activity against phagocytosed Staphylococcus aureus at clinical concentrations
AU - Ordway, Diane
AU - Viveiros, Miguel
AU - Leandro, Clara
AU - Arroz, Maria Jorge
AU - Molnar, Joseph
AU - Kristiansen, Jette E.
AU - Amaral, Leonard
PY - 2002/9
Y1 - 2002/9
N2 - Chlorpromazine (CPZ) has in vitro antimicrobial activity against Staphylococcus aureus at concentrations that greatly exceed those achieved clinically. It is concentrated by tissues that are rich in macrophages and it is active against phagocytosed mycobacteria when the concentration in the medium is compatible with that achieved clinically. In this report we show that nontoxic concentrations of CPZ below clinical levels have killing activity against S. aureus phagocytosed by human monocyte-derived macrophages that have nominal killing activity against these bacteria, Little or no resistance to the antimicrobial activity of this compound is anticipated to result because of its large number of cellular targets. Therefore, CPZ may have a role in the management of intracellular staphylococcal infections that normally require the use of antibiotics whose potential toxicity exceeds that associated with short-term management with CPZ.
AB - Chlorpromazine (CPZ) has in vitro antimicrobial activity against Staphylococcus aureus at concentrations that greatly exceed those achieved clinically. It is concentrated by tissues that are rich in macrophages and it is active against phagocytosed mycobacteria when the concentration in the medium is compatible with that achieved clinically. In this report we show that nontoxic concentrations of CPZ below clinical levels have killing activity against S. aureus phagocytosed by human monocyte-derived macrophages that have nominal killing activity against these bacteria, Little or no resistance to the antimicrobial activity of this compound is anticipated to result because of its large number of cellular targets. Therefore, CPZ may have a role in the management of intracellular staphylococcal infections that normally require the use of antibiotics whose potential toxicity exceeds that associated with short-term management with CPZ.
KW - Cellular immunity
KW - Chlorpromazine
KW - Intracellular activity
KW - Staphylococcus aureus
UR - http://www.scopus.com/inward/record.url?scp=0036745629&partnerID=8YFLogxK
UR - https://www.jiac-j.com/article/S1341-321X(02)71197-5/pdf
U2 - 10.1007/s10156-002-0188-4
DO - 10.1007/s10156-002-0188-4
M3 - Article
C2 - 12373485
AN - SCOPUS:0036745629
SN - 1341-321X
VL - Vol. 8
SP - 227
EP - 231
JO - Journal of Infection and Chemotherapy
JF - Journal of Infection and Chemotherapy
IS - n.º 3
ER -