TY - JOUR
T1 - Chitosan-based nanoparticles as drug delivery systems for doxorubicin
T2 - Optimization and modelling
AU - Soares, P
AU - Sousa, Ana Isabel
AU - Silva, Jorge
AU - Ferreira, Isabel M M
AU - Novo, Carlos M M
AU - Borges, João Paulo
N1 - Sem PDF.
This work is funded by FEDER funds through the COMPETE 2020 Program and National Funds through FCT-Portuguese Foundation for Science and Technology under the project number POCI-01-0145-FEDER-007688, Reference UID/CTM/50025. P.I.P. Soares acknowledges FCT for PhD grant SFRH/BD/81711/2011.
PY - 2016/8/20
Y1 - 2016/8/20
N2 - In the present work, two drug delivery systems were produced by encapsulating doxorubicin into chitosan and O-HTCC (ammonium-quaternary derivative of chitosan) nanoparticles. The results show that doxorubicin release is independent of the molecular weight and is higher at acidic pH (4.5) than at physiological pH. NPs with an average hydrodynamic diameter bellow 200 nm are able to encapsulate up to 70% and 50% of doxorubicin in the case of chitosan and O-HTCC nanoparticles, respectively. O-HTCC nanoparticles led to a higher amount of doxorubicin released than chitosan nanoparticles, for the same experimental conditions, although the release mechanism was not altered. A burst effect occurs within the first hours of release, reaching a plateau after 24 h. Fitting mathematical models to the experimental data led to a concordant release mechanism between most samples, indicating an anomalous or mixed release, which is in agreement with the swelling behavior of chitosan described in the literature.
AB - In the present work, two drug delivery systems were produced by encapsulating doxorubicin into chitosan and O-HTCC (ammonium-quaternary derivative of chitosan) nanoparticles. The results show that doxorubicin release is independent of the molecular weight and is higher at acidic pH (4.5) than at physiological pH. NPs with an average hydrodynamic diameter bellow 200 nm are able to encapsulate up to 70% and 50% of doxorubicin in the case of chitosan and O-HTCC nanoparticles, respectively. O-HTCC nanoparticles led to a higher amount of doxorubicin released than chitosan nanoparticles, for the same experimental conditions, although the release mechanism was not altered. A burst effect occurs within the first hours of release, reaching a plateau after 24 h. Fitting mathematical models to the experimental data led to a concordant release mechanism between most samples, indicating an anomalous or mixed release, which is in agreement with the swelling behavior of chitosan described in the literature.
KW - Chitosan
KW - Doxorubicin
KW - Drug delivery
KW - Mathematical modelling
KW - O-HTCC
UR - http://www.scopus.com/inward/record.url?scp=84964319827&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2016.03.028
DO - 10.1016/j.carbpol.2016.03.028
M3 - Article
C2 - 27178936
AN - SCOPUS:84964319827
SN - 0144-8617
VL - 147
SP - 304
EP - 312
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
ER -