Chiral Aziridination of Olefins Using a Chiral Sulfinamide as the Nitrogen Source

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Abstract

Chiral aziridination of cyclic alpha-bromoenones is achieved by the use of the lithium salt of (S-S)-(+)-p-toluenesulfinamide, which leads to products with diastereomeric excesses in the range of 30-65% using a simple protocol. A key factor associated with chiral induction is the incorporation of the reacting olefin in a cycle, indicating the importance of conformational restriction in the reacting double bond.
Original languageUnknown
Pages (from-to)145-149
JournalSynlett
Volumen/d
Issue number1
DOIs
Publication statusPublished - 1 Jan 2010

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