Chiral amplification of disodium cromoglycate chromonics induced by a codeine derivative

F. Berride, E. Troche-Pesqueira, António Gabriel Malagueta Feio, E. J. Cabrita, T. Sierra, A. Navarro-Vázquez, M. M. Cid

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7 Citations (Scopus)

Abstract

Chromonic liquid crystals (CLC) are lyotropic phases formed by discotic mesogens in water. Simple chiral dopants such as amino acids have been reported to turn chromonic liquid crystals into their cholesteric counterparts. Here we report a chirality amplification effect in the nematic phase of a 9 wt% disodium cromoglycate (DSCG) lyotropic liquid crystal (LLC) upon doping with a water-soluble codeine derivative. The transition on cooling the isotropic to the nematic phase showed the presence of homochiral spindle-shaped droplets (tactoids). NMR DOSY experiments on a triple gradient probe revealed a small degree of diffusion anisotropy for the alkaloid embedded in the liquid crystal structure. These results in combination with XRD, CD and POM experiments agree with a supramolecular aggregation model based on simple columnar stacks.

Original languageEnglish
Pages (from-to)6810-6815
Number of pages6
JournalSoft Matter
Volume13
Issue number38
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • RESIDUAL DIPOLAR COUPLINGS
  • LIQUID-CRYSTALS
  • WATER
  • NMR
  • ELUCIDATION
  • MESOPHASES
  • DIFFUSION
  • SYSTEM

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    Berride, F., Troche-Pesqueira, E., Feio, A. G. M., Cabrita, E. J., Sierra, T., Navarro-Vázquez, A., & Cid, M. M. (2017). Chiral amplification of disodium cromoglycate chromonics induced by a codeine derivative. Soft Matter, 13(38), 6810-6815. https://doi.org/10.1039/c7sm01227f