TY - JOUR
T1 - Chemical characterization and bioactivity of phytochemicals from Iberian endemic Santolina semidentata and strategies for ex situ propagation
AU - Gomes, Andreia
AU - Pimpão, Rui C.
AU - Fortalezas, Sofia
AU - Figueira, Inês
AU - Miguel, Célia
AU - Aguiar, Carlos
AU - Salgueiro, Lígia
AU - Cavaleiro, Carlos
AU - Gonçalves, Maria José
AU - Clemente, Adelaide
AU - Costa, Catarina
AU - Martins-Loução, Maria Amélia
AU - Boavida, Ricardo
AU - Santos, Cláudia N.
PY - 2015/11/5
Y1 - 2015/11/5
N2 - Asteraceae family members are well-known for their medicinal potential, comprising several properties that make them unique among plants. Here we focus on Santolina semidentata, an endemic plant from the Iberian Peninsula, not yet described for its medicinal properties. Phytochemical characterization of S. semidentata was performed, concerning total phenol content, flavonoid content, antioxidant capacity, HPLC-DAD profile, acetylcholinesterase inhibitory capacity, cytotoxicity and neuroprotective effect in a human neurodegeneration cell model. Moreover, essential oil composition and antifungal activity were also analised. This oil might be useful for therapeutical purposes, particularly in the treatment of dermatophytosis. S. semidentata potential for neuroprotection was revealed by acetylcholinesterase inhibitory capacity and also by an effective protective effect in human neuronal cells. Furthermore, different seed conservation protocols, as well as successful in vitro propagation were established which may be useful when integrated in a broad strategy for the conservation of these endemic plants and their sustainable use for potential biotechnological applications. The results presented here greatly contribute to value this species regarding its potential as a source of phytochemicals with prospective neuroprotective health benefits, either as alternative neuroprotective drugs or as leads for synthetizing more effective molecules.
AB - Asteraceae family members are well-known for their medicinal potential, comprising several properties that make them unique among plants. Here we focus on Santolina semidentata, an endemic plant from the Iberian Peninsula, not yet described for its medicinal properties. Phytochemical characterization of S. semidentata was performed, concerning total phenol content, flavonoid content, antioxidant capacity, HPLC-DAD profile, acetylcholinesterase inhibitory capacity, cytotoxicity and neuroprotective effect in a human neurodegeneration cell model. Moreover, essential oil composition and antifungal activity were also analised. This oil might be useful for therapeutical purposes, particularly in the treatment of dermatophytosis. S. semidentata potential for neuroprotection was revealed by acetylcholinesterase inhibitory capacity and also by an effective protective effect in human neuronal cells. Furthermore, different seed conservation protocols, as well as successful in vitro propagation were established which may be useful when integrated in a broad strategy for the conservation of these endemic plants and their sustainable use for potential biotechnological applications. The results presented here greatly contribute to value this species regarding its potential as a source of phytochemicals with prospective neuroprotective health benefits, either as alternative neuroprotective drugs or as leads for synthetizing more effective molecules.
KW - Acetylcholinesterase inhibitor
KW - Essential oil
KW - Iberian endemism
KW - Neuroprotection
KW - Phytomolecules
KW - Polyphenol
KW - Propagation protocol
KW - Santolina semidentata
UR - http://www.scopus.com/inward/record.url?scp=84930938252&partnerID=8YFLogxK
U2 - 10.1016/j.indcrop.2015.04.037
DO - 10.1016/j.indcrop.2015.04.037
M3 - Article
AN - SCOPUS:84930938252
SN - 0926-6690
VL - 74
SP - 505
EP - 513
JO - Industrial Crops and Products
JF - Industrial Crops and Products
ER -