Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 129-138 |
| Number of pages | 10 |
| Journal | International Journal of Biological Macromolecules |
| Volume | 86 |
| DOIs | |
| Publication status | Published - 1 May 2016 |
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Keywords
- (3-6): Sulfated pullulan
- Tetraalkylammonium pullulan
- Polyelectrolyte complexation
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Charged pullulan derivatives for the development of nanocarriers by polyelectrolyte complexation. / Dionisio, M.; Braz, L.; Corvo, M.; Lourenço, J. P.; Grenha, A.; Rosa Da Costa, A.m.
In: International Journal of Biological Macromolecules, Vol. 86, 01.05.2016, p. 129-138.Research output: Contribution to journal › Article
TY - JOUR
T1 - Charged pullulan derivatives for the development of nanocarriers by polyelectrolyte complexation
AU - Dionisio, M.
AU - Braz, L.
AU - Corvo, M.
AU - Lourenço, J. P.
AU - Grenha, A.
AU - Rosa Da Costa, A.m.
N1 - Sem PDF. National Portuguese funding through FCT-Fundacao para a Ciencia e a Tecnologia (PTDC/SAU-FCF/100291/2008; PEst-OE/EQB/LA0023/2013; PEst-OE/QUI/UI4023/2011; UID/Multi/04378/2013,UID/CTM/50025/2013) FEDER funds through the COMPETE Programme Fundacao para a Ciencia e a Tecnologia Portuguese National NMR Network (RNRMN)
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Pullulan, a neutral polysaccharide, was chemically modified in order to obtain two charged derivatives: reaction with SO3 center dot DMF complex afforded a sulfate derivative (SP), while reaction with glycidyltrimethylammonium chloride gave a quaternary ammonium salt (AP). The presence of the charged groups was confirmed by FTIR. Assessment of the positions where the reaction took place was based on H-1- and C-13 NMR (COSY, HSQC-TOCSY, HSQC-DEPT, and HMBC) experiments. Estimation of the degree of substitution (DS) was made from elemental analysis data, and further confirmed by NMR peak areas in the case of AP. These new derivatives showed the capability to condense with each other, forming nanoparticles with the ability to associate a model protein (BSA) and displaying adequate size for drug delivery applications, therefore making them good candidates for the production of pullulan-based nanocarriers by polyelectrolyte complexation
AB - Pullulan, a neutral polysaccharide, was chemically modified in order to obtain two charged derivatives: reaction with SO3 center dot DMF complex afforded a sulfate derivative (SP), while reaction with glycidyltrimethylammonium chloride gave a quaternary ammonium salt (AP). The presence of the charged groups was confirmed by FTIR. Assessment of the positions where the reaction took place was based on H-1- and C-13 NMR (COSY, HSQC-TOCSY, HSQC-DEPT, and HMBC) experiments. Estimation of the degree of substitution (DS) was made from elemental analysis data, and further confirmed by NMR peak areas in the case of AP. These new derivatives showed the capability to condense with each other, forming nanoparticles with the ability to associate a model protein (BSA) and displaying adequate size for drug delivery applications, therefore making them good candidates for the production of pullulan-based nanocarriers by polyelectrolyte complexation
KW - (3-6): Sulfated pullulan
KW - Tetraalkylammonium pullulan
KW - Polyelectrolyte complexation
U2 - 10.1016/j.ijbiomac.2016.01.054
DO - 10.1016/j.ijbiomac.2016.01.054
M3 - Article
VL - 86
SP - 129
EP - 138
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
SN - 0141-8130
ER -