Characterization of Envelope Surface Glycoprotein from HIV-2 Primary Isolates with Different Coreceptor Usage Profile

Paula Cerejo, Quirina Santos-Costa, Marta Calado, Maria Espírito-Santo, Ricardo Parreira, José Miguel Azevedo-Pereira

Research output: Contribution to journalArticle

Abstract

The main goal of this work was to identify molecular signatures in envelope surface glycoprotein that may be correlated with coreceptor usage by different human immunodeficiency virus (HIV)-2 strains. From inspection of aligned HIV-2 sequences, we verified that V1/V2 region showed the highest degree of amino acid sequence heterogeneity, including polymorphisms in N-linked glycosylation sites, sequence, and length. Furthermore, we did not find any correlation between the net charge and specific amino acid positions in V3 region with any particular coreceptor usage pattern. In conclusion, we showed that for HIV-2, the genetic determinants for coreceptor usage are distinct from those of HIV-1. More specifically, we did not identify any molecular signature, based on discrete amino acid positions either in V1/V2 or in V3 regions, which could be assigned to the preferential usage of a specific coreceptor.

Original languageEnglish
Pages (from-to)218-221
Number of pages4
JournalAIDS Research and Human Retroviruses
Volume34
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • coreceptor usage
  • envelope glycoprotein
  • HIV-2
  • molecular determinants

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