Abstract
PA-785
Background
Health Care Workers (HCW) faced a high risk of
exposure to SARS-CoV-2.
In the present study, we described the presence and duration of
anti-S and anti-N IgG antibodies against SARS-CoV-2 among
HCW to evaluate the immunity response induced by either
SARS-CoV-2 infection or COVID-19 vaccination.
Methods Case-cohort study of 465 HCW from hospitals from
the islands of Santiago and São Vicente, conducted in 2021, of
which 217 were cases (SARS-CoV-2 infection) and 248 controls
(no SARS-CoV-2 infection). Study participants were followed-up
until 6 months after recruitment for longitudinal analysis of
antibody dynamics, independently of SARS-CoV-2 vaccination
status. ELISA test for anti-N and anti-S1 SARS-CoV-2 IgG
antibodies were performed on serum samples using collected at
baseline (T0) and at 6 months (T6). Among vaccinated
participants, these two time points corresponded to a mean time
from vaccination of 115 (SD: 60 days) and 350 days (SD: 74 days)
respectively.
Results Of the 396/465 (85%) tested for anti-SARS-CoV-2
antibodies at T0, 36% (n=66/185) of cases and 12% of controls
(n=26/211) were positive for anti-N.
Among the vaccinated at T0 165/166 (96%) cases and 200/205
(97%) controls were positive for anti-S1.
The anti-S1 among the case and control group remained high at
T6, with 177/179 (99%) cases and 197/198 (99%) controls of
HCW tested at 6 months being positive.
Among 250 (67%) vaccinated, who were anti-N negative at T0-
,115(32%) remain negative at T6.
Conclusion These findings showed that only 31% of cases had
anti-N. The results also showed positive results for IgG anti-N in
HCW without previous SARS-CoV-2 infection, which could be
considered asymptomatic cases. Most vaccinated participants
had Anti-S after vaccination and they remained high during the 6
months of follow-up. Nonetheless, at least (65/354) had a new
infection (32 cases, 33 controls).
Funding: EDCTP (RIA2020EF-3049)
Background
Health Care Workers (HCW) faced a high risk of
exposure to SARS-CoV-2.
In the present study, we described the presence and duration of
anti-S and anti-N IgG antibodies against SARS-CoV-2 among
HCW to evaluate the immunity response induced by either
SARS-CoV-2 infection or COVID-19 vaccination.
Methods Case-cohort study of 465 HCW from hospitals from
the islands of Santiago and São Vicente, conducted in 2021, of
which 217 were cases (SARS-CoV-2 infection) and 248 controls
(no SARS-CoV-2 infection). Study participants were followed-up
until 6 months after recruitment for longitudinal analysis of
antibody dynamics, independently of SARS-CoV-2 vaccination
status. ELISA test for anti-N and anti-S1 SARS-CoV-2 IgG
antibodies were performed on serum samples using collected at
baseline (T0) and at 6 months (T6). Among vaccinated
participants, these two time points corresponded to a mean time
from vaccination of 115 (SD: 60 days) and 350 days (SD: 74 days)
respectively.
Results Of the 396/465 (85%) tested for anti-SARS-CoV-2
antibodies at T0, 36% (n=66/185) of cases and 12% of controls
(n=26/211) were positive for anti-N.
Among the vaccinated at T0 165/166 (96%) cases and 200/205
(97%) controls were positive for anti-S1.
The anti-S1 among the case and control group remained high at
T6, with 177/179 (99%) cases and 197/198 (99%) controls of
HCW tested at 6 months being positive.
Among 250 (67%) vaccinated, who were anti-N negative at T0-
,115(32%) remain negative at T6.
Conclusion These findings showed that only 31% of cases had
anti-N. The results also showed positive results for IgG anti-N in
HCW without previous SARS-CoV-2 infection, which could be
considered asymptomatic cases. Most vaccinated participants
had Anti-S after vaccination and they remained high during the 6
months of follow-up. Nonetheless, at least (65/354) had a new
infection (32 cases, 33 controls).
Funding: EDCTP (RIA2020EF-3049)
| Original language | English |
|---|---|
| Pages | 171 |
| Publication status | Published - 2023 |
| Event | EDCTP Forum: Partnering for Global Health Research Innovation and Impact in Africa - Paris, France, Paris, France Duration: 7 Nov 2023 → 10 Nov 2023 Conference number: 11 |
Conference
| Conference | EDCTP Forum |
|---|---|
| Abbreviated title | EDCTP Forum |
| Country/Territory | France |
| City | Paris |
| Period | 7/11/23 → 10/11/23 |
