Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics

João D. Seixas, Abhik Mukhopadhyay, Teresa Sacadura Santos-silva, Leo Edmond Otterbein, David J. Gallo, Sandra S. Rodrigues, Bruno Guerreiro, Ana M. L. Gonçalves, Nuno Penacho, Ana Rita Marques, Ana Catarina Coelho, Patricia Matias Reis, Maria João Romão, C. C. Romao

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The complex fac-{[}Mo(CO)(3)(histidinate)]Na has been reported to be an effective CO-Releasing Molecule in vivo, eliciting therapeutic effects in several animal models of disease. The CO releasing profile of this complex in different settings both in vitro and in vivo reveals that the compound can readily liberate all of its three CO equivalents under biological conditions. The compound has low toxicity and cytotoxicity and is not hemolytic. CO release is accompanied by a decrease in arterial blood pressure following administration in vivo. We studied its behavior in solution and upon the interaction with proteins. Reactive oxygen species (ROS) generation upon exposure to air and polyoxomolybdate formation in soaks with lysozyme crystals were observed as processes ensuing from the decomposition of the complex and the release of CO.
Original languageEnglish
Pages (from-to)5985-5998
JournalDalton Transactions
Volume42
Issue number17
DOIs
Publication statusPublished - 7 May 2013

Keywords

  • Cytotoxicity
  • Organometallics
  • Molybdenum compounds

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