Characterization of a Biocomposite of Electrospun PVDF Membranes with Embedded BaTiO3 Micro- and Nanoparticles

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Abstract

Damage to bone tissue is a common health issue that tends to increase in severity with age and other underlying conditions. To take advantage of the piezoelectric effect on bone remodulation, piezoelectric materials can be used to fill patients bone defects. Polyvinylidene fluoride (PVDF) and barium titanate (BaTiO3) are both well-known polymeric and ceramic biomaterials, respectively, as well as piezoelectric at room temperature. To mimic the extracellular matrix, PVDF membranes were produced by electrospinning onto a rotating drum to promote the alignment of fibers and micro- and nano-sized tetragonal BaTiO3 particles were embedded into these membranes to try to enhance the piezoelectric response and, therefore, bioactivity. After defining the best deposition parameters to produce pure PVDF membranes, the same parameters were carried over for the embedded membranes and both were characterized, revealing that the proposed method for obtaining β-phase PVDF (the polymer phase with highest piezoelectric coefficient) through electrospinning is viable, producing fibers with coherent diameters and alignment. The presence of barium titanate conferred bioactivity to the membranes and caused a decrease in fibers’ diameter and in superficial charge density.
Original languageEnglish
Pages (from-to)531-542
Number of pages12
JournalMacromol
Volume2
Issue number4
DOIs
Publication statusPublished - 17 Nov 2022

Keywords

  • BaTiO
  • bone regeneration
  • electrospinning
  • functional biomaterials
  • piezoelectricity
  • PVDF

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