Chapter 7

Emerging Systems Toxicology Approaches in Nanosafety Assessment

Pedro M. Costa, Bengt Fadeel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Engineered nanomaterials are being developed for a variety of applications. However, the increasing use of nanomaterials has led to concerns about their potential adverse effects on human health and the environment. It is now understood that effective risk assessment of nanomaterials would benefit from a comprehensive understanding of their toxicological mechanisms, which is difficult to achieve with traditional, low-throughput, single-endpoint approaches. However, global omics approaches with which to assess changes in genes, proteins, and metabolites in cells and tissues are now being introduced in nano(eco)toxicology. In a systems toxicology paradigm, quantitative and predictive models of nanomaterial behaviour in a biological system are developed, to support and inform risk assessment. In this chapter, we discuss omics technologies and their application in nanotoxicology.

Original languageEnglish
Title of host publicationNanotoxicology
Subtitle of host publicationExperimental and Computational Perspectives
PublisherRoyal Society of Chemistry
Pages174-202
Number of pages29
Volume2018-January
Edition35
ISBN (Electronic)978-1-78801-259-1
ISBN (Print)978-1-78262-158-4
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameIssues in Toxicology
Number35
Volume2018-January
ISSN (Print)1757-7179
ISSN (Electronic)1757-7187

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Costa, P. M., & Fadeel, B. (2018). Chapter 7: Emerging Systems Toxicology Approaches in Nanosafety Assessment. In Nanotoxicology: Experimental and Computational Perspectives (35 ed., Vol. 2018-January, pp. 174-202). (Issues in Toxicology; Vol. 2018-January, No. 35). Royal Society of Chemistry. https://doi.org/10.1039/9781782623922-00174