Changes of simple mucin type antigens (Tn, sTn, t) seem to be correlated with neoplastic development in Barrett's metaplasia

Jorge Manuel de Oliveira Soares; Maria Paula Guerreiro Chaves Pascoal; Raquel Nunes Marta

Changes of simple mucin type antigens (Tn, sTn, t) seem to be correlated with neoplastic development in Barrett's metaplasia

Jorge Manuel de Oliveira Soares, Maria Paula Guerreiro Chaves Pascoal, Raquel Nunes Marta

NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

This study aimed at evaluating by immunohistochemistry the expression of simple mucin type carbohydrate antigens (Tn, sTn, T) in Barrett's esophagus and associated adenocarcinoma. The series includes surgical (12 pts) and endoscopic biopsy (31 pts) specimens containing columnar-lined mucosa with and without areas of specialized intestinal metaplasia and adenocarcinoma. Both types of metaplastic elements as well as neoplastic cells showed altered simple mucin-type carbohydrate antigens. Alterations of mucin synthesis are associated with the development of neoplasia in Barrett's esophagus, involving columnar cells in addition to goblet non-columnar cells.

Original language	Unknown
Title of host publication	RECENT ADVANCES IN DISEASES OF THE ESOPHAGUS
Pages	137-142
Publication status	Published - 1 Jan 2001
Event	8th World Congress of the International-Society-for-Diseases-of-the-Esophagus - Duration: 1 Jan 2001 → …

Conference

Conference	8th World Congress of the International-Society-for-Diseases-of-the-Esophagus
Period	1/01/01 → …

Cite this

@inproceedings{91663fee4afa493c95b67b55234a23a0,

title = "Changes of simple mucin type antigens (Tn, sTn, t) seem to be correlated with neoplastic development in Barrett's metaplasia",

abstract = "This study aimed at evaluating by immunohistochemistry the expression of simple mucin type carbohydrate antigens (Tn, sTn, T) in Barrett's esophagus and associated adenocarcinoma. The series includes surgical (12 pts) and endoscopic biopsy (31 pts) specimens containing columnar-lined mucosa with and without areas of specialized intestinal metaplasia and adenocarcinoma. Both types of metaplastic elements as well as neoplastic cells showed altered simple mucin-type carbohydrate antigens. Alterations of mucin synthesis are associated with the development of neoplasia in Barrett's esophagus, involving columnar cells in addition to goblet non-columnar cells.",

keywords = "EXPRESSION, CANCER, SIALOSYL-TN, CARCINOMAS, ESOPHAGUS",

author = "Soares, {Jorge Manuel de Oliveira} and Pascoal, {Maria Paula Guerreiro Chaves} and Marta, {Raquel Nunes}",

year = "2001",

month = jan,

day = "1",

language = "Unknown",

pages = "137--142",

booktitle = "RECENT ADVANCES IN DISEASES OF THE ESOPHAGUS",

note = "8th World Congress of the International-Society-for-Diseases-of-the-Esophagus ; Conference date: 01-01-2001",

}

Changes of simple mucin type antigens (Tn, sTn, t) seem to be correlated with neoplastic development in Barrett's metaplasia. / Soares, Jorge Manuel de Oliveira ; Pascoal, Maria Paula Guerreiro Chaves ; Marta, Raquel Nunes.
RECENT ADVANCES IN DISEASES OF THE ESOPHAGUS. 2001. p. 137-142.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Changes of simple mucin type antigens (Tn, sTn, t) seem to be correlated with neoplastic development in Barrett's metaplasia

AU - Soares, Jorge Manuel de Oliveira

AU - Pascoal, Maria Paula Guerreiro Chaves

AU - Marta, Raquel Nunes

PY - 2001/1/1

Y1 - 2001/1/1

N2 - This study aimed at evaluating by immunohistochemistry the expression of simple mucin type carbohydrate antigens (Tn, sTn, T) in Barrett's esophagus and associated adenocarcinoma. The series includes surgical (12 pts) and endoscopic biopsy (31 pts) specimens containing columnar-lined mucosa with and without areas of specialized intestinal metaplasia and adenocarcinoma. Both types of metaplastic elements as well as neoplastic cells showed altered simple mucin-type carbohydrate antigens. Alterations of mucin synthesis are associated with the development of neoplasia in Barrett's esophagus, involving columnar cells in addition to goblet non-columnar cells.

AB - This study aimed at evaluating by immunohistochemistry the expression of simple mucin type carbohydrate antigens (Tn, sTn, T) in Barrett's esophagus and associated adenocarcinoma. The series includes surgical (12 pts) and endoscopic biopsy (31 pts) specimens containing columnar-lined mucosa with and without areas of specialized intestinal metaplasia and adenocarcinoma. Both types of metaplastic elements as well as neoplastic cells showed altered simple mucin-type carbohydrate antigens. Alterations of mucin synthesis are associated with the development of neoplasia in Barrett's esophagus, involving columnar cells in addition to goblet non-columnar cells.

KW - EXPRESSION

KW - CANCER

KW - SIALOSYL-TN

KW - CARCINOMAS

KW - ESOPHAGUS

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BT - RECENT ADVANCES IN DISEASES OF THE ESOPHAGUS

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