Changes in albumin-to-creatinine ratio at 12-month follow-up in patients undergoing renal denervation

Henrique Sousa, Patrícia Branco, Manuel de Sousa Almeida, Pedro de Araújo Gonçalves, Augusta Gaspar, Hélder Dores, João Rodrigo Mesquita, Maria João Andrade, Nuno Neuparth, Ana Aleixo, Miguel Mendes, José Diogo Barata

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Introduction: Sympathetic renal denervation (RDN) was developed as a treatment for the management of patients with resistant hypertension. This procedure may have a positive impact on hypertension-related target organ damage, particularly renal disease, but the evidence is still limited. Objective: To assess the impact of RDN on the albumin-to-creatinine ratio (ACR) at 12-month follow-up. Methods and Results: From a single-center prospective registry including 65 patients with resistant hypertension undergoing renal denervation, 31 patients with complete baseline and 12-month follow-up blood pressure (BP) measurements (both office and 24-h ambulatory blood pressure monitoring [ABPM]) and ACR were included in the present study. Mean age was 65±7 years, 52% were female, most (90%) had been diagnosed with hypertension for more than 10 years, 71% had type 2 diabetes and 33% had vascular disease in at least one territory. Mean estimated glomerular filtration rate was 73.6±25.1 ml/min/1.73 m2 and 15 patients (48%) had an ACR >30 mg/g. After 12 months, 22 patients were considered BP responders (73%). ACR decreased significantly from a median of 25.8 mg/g (interquartile range [IQR] 9.0-574.0 mg/g) to 14.8 mg/g (IQR 4.5-61.0 mg/g, p=0.007). When the results were split according to systolic BP responder status on ABPM, we found a significant reduction in responders (from 25.6 mg/g [IQR 8.7-382.8 mg/g] to 15.9 mg/g [IQR 4.4-55.0 mg/g], p=0.009), and a numerical decrease in the non-responder subgroup (from 165.0 mg/g [IQR 8.8-1423.5 mg/g] to 13.6 mg/dl [IQR 5.7-1417.0 mg/g], p=0.345). Conclusions: Besides significant reductions in blood pressure (both office and 24-h ABPM), renal denervation was associated with a significant reduction in ACR, a recognized marker of target organ damage.

Original languageEnglish
Pages (from-to)343-351
Number of pages8
JournalRevista Portuguesa de Cardiologia
Issue number5
Early online date26 Apr 2017
Publication statusPublished - May 2017


  • Albuminuria
  • Blood pressure
  • Renal denervation
  • Resistant hypertension


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