Challenges in matrix metalloproteinases inhibition

Helena Laronha, Inês Carpinteiro, Jaime Portugal, Ana Cristina Azul, Mário Polido, Krasimira T. Petrova, Madalena Salema-Oom, Jorge Caldeira

Research output: Contribution to journalReview articlepeer-review

41 Citations (Scopus)
18 Downloads (Pure)


Matrix metalloproteinases are enzymes that degrade the extracellular matrix. They have different substrates but similar structural organization. Matrix metalloproteinases are involved in many physiological and pathological processes and there is a need to develop inhibitors for these enzymes in order to modulate the degradation of the extracellular matrix (ECM). There exist two classes of inhibitors: endogenous and synthetics. The development of synthetic inhibitors remains a great challenge due to the low selectivity and specificity, side effects in clinical trials, and instability. An extensive review of currently reported synthetic inhibitors and description of their properties is presented.

Original languageEnglish
Article number717
Issue number5
Publication statusPublished - 5 May 2020


  • Matrix metalloproteinases
  • Synthetic inhibitors
  • TIMP


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