TY - JOUR
T1 - Chalcone derivatives:
T2 - promising starting points for drug design
AU - Gomes, Marcelo N.
AU - Muratov, Eugene N.
AU - Pereira, Maristela
AU - Peixoto, Josana C.
AU - Rosseto, Lucimar P.
AU - Cravo, Pedro V.L.
AU - Andrade, Carolina H.
AU - Neves, Bruno J.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Medicinal chemists continue to be fascinated by chalcone derivatives because of their simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a variety of promising biological activities. However, chalcones have still not garnered deserved attention, especially considering their high potential as chemical sources for designing and developing new effective drugs. In this review, we summarize current methodological developments towards the design and synthesis of new chalcone derivatives and state-of-the-art medicinal chemistry strategies (bioisosterism, molecular hybridization, and pro-drug design). We also highlight the applicability of computer-assisted drug design approaches to chalcones and address how this may contribute to optimizing research outputs and lead to more successful and cost-effective drug discovery endeavors. Lastly, we present successful examples of the use of chalcones and suggest possible solutions to existing limitations.
AB - Medicinal chemists continue to be fascinated by chalcone derivatives because of their simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a variety of promising biological activities. However, chalcones have still not garnered deserved attention, especially considering their high potential as chemical sources for designing and developing new effective drugs. In this review, we summarize current methodological developments towards the design and synthesis of new chalcone derivatives and state-of-the-art medicinal chemistry strategies (bioisosterism, molecular hybridization, and pro-drug design). We also highlight the applicability of computer-assisted drug design approaches to chalcones and address how this may contribute to optimizing research outputs and lead to more successful and cost-effective drug discovery endeavors. Lastly, we present successful examples of the use of chalcones and suggest possible solutions to existing limitations.
KW - Chalcone derivatives
KW - Chalcone synthesis
KW - Computer-assisted drug design
KW - Molecular modification strategies
KW - Natural products
UR - http://www.scopus.com/inward/record.url?scp=85028021989&partnerID=8YFLogxK
U2 - 10.3390/molecules22081210
DO - 10.3390/molecules22081210
M3 - Review article
C2 - 28757583
AN - SCOPUS:85028021989
VL - 22
SP - 1210
EP - 1235
JO - Molecules
JF - Molecules
IS - 8
M1 - 1210
ER -