@article{ab3b42b8f2884870a898e82fccf4f1ea,
title = "Cellulose acetate fibres loaded with daptomycin for metal implant coatings",
abstract = "Multifunctional polymeric coatings containing drug delivery vehicles can play a key role in preventing/reducing biofilm formation on implant surfaces. Their requirements are biocompatibility, good adhesion, and controllable drug release. Although cellulose acetate (CA) films and membranes are widely studied for scaffolding, their applications as a protective coating and drug delivery vehicle for metal implants are scarce. The reason is that adhesion to stainless steel (SS) substrates is non-trivial. Grinding SS substrates enhances the adhesion of dip-coated CA films while the adhesion of electrospun CA membranes is improved by an electrosprayed chitosan intermediate layer. PMMA microcapsules containing daptomycin have been successfully incorporated into CA films and fibres. The released drug concentration of 3 × 10−3 mg/mL after 120 min was confirmed from the peak luminescence intensity under UV radiation of simulated body fluid (SBF) after immersion of the fibres.",
keywords = "Cellulose acetate, Daptomycin, Electrospinning, Metal implants, Polymeric coatings",
author = "Jaime Faria and Bruno Dion{\'i}sio and {\'I}ris Soares and Baptista, {Ana Catarina} and Ana Marques and Gon{\c c}alves, {L{\'i}dia M.} and Bettencourt, {Ana Francisca} and Carlos Baleiz{\~a}o and Ferreira, {Isabel M. M.}",
note = "Funding Information: info:eu-repo/grantAgreement/EC/H2020/645241/EU# info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50025%2F2020/PT# info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04138%2F2020/PT# info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT# info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00100%2F2020/PT# info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00100%2F2020/PT# info:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03143%2F2017%2FCP1476%2FCT0005/PT# info:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F143032%2F2018/PT# info:eu-repo/grantAgreement/EC/H2020/647596/EU# This work was partially funded by H2020-ICT-2014-1, RIA, The authors would like to thank the use of the electrospinning apparatus at the Biomaterials Laboratory from Soft and Bio-functional Materials Group (CENIMAT/I3N). Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",
year = "2022",
month = jan,
day = "15",
doi = "10.1016/j.carbpol.2021.118733",
language = "English",
volume = "276",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Elsevier",
}