CD4+ and CD8+ cell populations in HIV-positive women with cervical squamous intra-epithelial lesions and squamous cell carcinoma

Maria José Brito, Pedro Sequeira, Iryna Silva, Ana Quintas, Catarina Martins, Ana Félix

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Abstract

INTRODUCTION: This study aimed to analyse cervix lymphocytic populations in HIV + and HIV- patients and correlate different cervical lesions with HIV viral load and presence of high-risk HPV types.

MATERIAL AND METHODS: A total of 132 histological specimens from 40 HIV + and 72 HIV- patients were evaluated for CD4+ and CD8+ T cell distribution, presence of high-risk HPV types, peripheral blood HIV viral load and CD4+/CD8+ ratio.

RESULTS: High-grade squamous intraepithelial lesions (HSIL) and squamous cell carcinoma (SCC) from HIV + patients had lower CD4+ T cell scores compared with HIV- patients. In all lesion groups, HIV + patients presented higher epithelial and stromal CD8+ T cell scores. HIV viral load was more often detectable in patients with SCC than in those with low-grade squamous intraepithelial lesion (LSIL) (p = 0.0409). HSIL HIV + patients had lower circulating CD4+ T cell counts (p = 0.0434) and CD4+/CD8+ ratio (p = 0.0378) compared with LSIL HIV + patients. High-risk HPV types other than 16 and 18/45 were more prevalent in the HIV + group.

DISCUSSION: These results support an imbalance between cervical CD4+ and CD8+ T lymphocytes of HIV + patients with SIL and SCC, with increased CD8+ infiltrate density with lesion severity, even in patients with immune system recovery under cART.

Original languageEnglish
Pages (from-to)370-377
JournalInternational Journal of Infectious Diseases
Volume103
Early online date3 Nov 2020
DOIs
Publication statusPublished - Feb 2021

Keywords

  • Carcinoma
  • CD4+ T cell
  • CD8+ T cell
  • Cervix
  • HIV
  • Viral load

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