CATIONIC CORE-SHELL POLYMERS

Vasco Daniel Bigas Bonifácio (Inventor), Dalila Madeira do Nascimento Mil-Homens (Inventor), Sandra Cistina Nunes Trigo Fernandes Pinto (Inventor), Rita Figueiredo Pires (Inventor), Arsénio do Carmo Sales Mendes Fialho (Inventor), Nuno Filipe Santos Bernardes (Inventor), Ana Isabel Nobre M.A. de Oliveira Ricardo (Inventor)

Research output: PatentInternational PCT application

Abstract

The present invention relates to novel cationic core-shell polymers comprising a core consisting of a polyurea dendrimer of generation n conjugated to a layer consisting of a cationic olygoethyleneimine polymer with a polymerization degree r, which are synthesized in a sustainable, simple and low-cost manner. In addition to their low toxicity and low hemolysis, these polymers also have an inherent biological activity. These polymers may also be included in formulations. The polymers of the present invention and formulations comprising same can be used in the treatment of infections caused by pathogenic bacteria and fungi and also in the treatment of several kinds of cancer.

Original languageEnglish
Patent numberWO2022071819
IPCC08G 83/ 00 A I, A61K47/34, A61P31/00,C08G81/00
Priority date1/10/20
Filing date1/10/21
Publication statusPublished - 7 Apr 2022

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