TY - JOUR
T1 - Cation-mediated gelation of the fucose-rich polysaccharide FucoPol
T2 - preparation and characterization of hydrogel beads and their cytotoxicity assessment
AU - Fialho, Letícia
AU - Araújo, Diana
AU - Alves, Vitor D.
AU - Roma-Rodrigues, Catarina
AU - Baptista, Pedro V.
AU - Fernandes, Alexandra R.
AU - Freitas, Filomena
AU - Reis, Maria A. M.
N1 - FCT/MEC (UID/Multi/04378/2019).
PEst-OE/AGR/UI0245/2014.
POCI-01-0145-FEDER-007728 and POCI-01-0145-FEDER - 007265.
SFRH/BD/140829/2018.
SFRH/BPD/124612/2016.
PY - 2021
Y1 - 2021
N2 - This study describes for the first time the iron- and copper-mediated gelation of FucoPol, fucose-rich bacterial polysaccharide. The ability of FucoPol to gel in the presence of metal cations, including iron(III) and copper(II), was used for the preparation of hydrogel beads. Iron mediated the formation of stable and not cytotoxic gel beads, while copper resulted in fragile and cytotoxic ones. Copper-mediated beads coated with an iron-mediated gel layer were more stable and had reduced cytotoxicity. The resulting polymeric structures had differing morphology, physical properties and cytotoxicity, which support their use in several applications, including biomedicine, agriculture and bioremediation.
AB - This study describes for the first time the iron- and copper-mediated gelation of FucoPol, fucose-rich bacterial polysaccharide. The ability of FucoPol to gel in the presence of metal cations, including iron(III) and copper(II), was used for the preparation of hydrogel beads. Iron mediated the formation of stable and not cytotoxic gel beads, while copper resulted in fragile and cytotoxic ones. Copper-mediated beads coated with an iron-mediated gel layer were more stable and had reduced cytotoxicity. The resulting polymeric structures had differing morphology, physical properties and cytotoxicity, which support their use in several applications, including biomedicine, agriculture and bioremediation.
KW - cytotoxicity
KW - FucoPol
KW - hydrogel beads
UR - http://www.scopus.com/inward/record.url?scp=85075476906&partnerID=8YFLogxK
U2 - 10.1080/00914037.2019.1695205
DO - 10.1080/00914037.2019.1695205
M3 - Article
AN - SCOPUS:85075476906
SN - 0091-4037
VL - 70
JO - International Journal of Polymeric Materials and Polymeric Biomaterials
JF - International Journal of Polymeric Materials and Polymeric Biomaterials
IS - 2
ER -