Cation-mediated gelation of the fucose-rich polysaccharide FucoPol: preparation and characterization of hydrogel beads and their cytotoxicity assessment

Research output: Contribution to journalArticle

Abstract

This study describes for the first time the iron- and copper-mediated gelation of FucoPol, fucose-rich bacterial polysaccharide. The ability of FucoPol to gel in the presence of metal cations, including iron(III) and copper(II), was used for the preparation of hydrogel beads. Iron mediated the formation of stable and not cytotoxic gel beads, while copper resulted in fragile and cytotoxic ones. Copper-mediated beads coated with an iron-mediated gel layer were more stable and had reduced cytotoxicity. The resulting polymeric structures had differing morphology, physical properties and cytotoxicity, which support their use in several applications, including biomedicine, agriculture and bioremediation.

Original languageEnglish
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
DOIs
Publication statusE-pub ahead of print - 1 Jan 2019

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Fucose
Hydrogel
Gelation
Cytotoxicity
Polysaccharides
Hydrogels
Cations
Copper
Iron
Positive ions
Gels
Bacterial Polysaccharides
Bioremediation
Agriculture
Physical properties
Metals

Keywords

  • cytotoxicity
  • FucoPol
  • hydrogel beads

Cite this

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title = "Cation-mediated gelation of the fucose-rich polysaccharide FucoPol: preparation and characterization of hydrogel beads and their cytotoxicity assessment",
abstract = "This study describes for the first time the iron- and copper-mediated gelation of FucoPol, fucose-rich bacterial polysaccharide. The ability of FucoPol to gel in the presence of metal cations, including iron(III) and copper(II), was used for the preparation of hydrogel beads. Iron mediated the formation of stable and not cytotoxic gel beads, while copper resulted in fragile and cytotoxic ones. Copper-mediated beads coated with an iron-mediated gel layer were more stable and had reduced cytotoxicity. The resulting polymeric structures had differing morphology, physical properties and cytotoxicity, which support their use in several applications, including biomedicine, agriculture and bioremediation.",
keywords = "cytotoxicity, FucoPol, hydrogel beads",
author = "Let{\'i}cia Fialho and Diana Ara{\'u}jo and Alves, {Vitor D.} and Catarina Roma-Rodrigues and Baptista, {Pedro V.} and Fernandes, {Alexandra R.} and Filomena Freitas and Reis, {Maria A. M.}",
note = "FCT/MEC (UID/Multi/04378/2019). PEst-OE/AGR/UI0245/2014. POCI-01-0145-FEDER-007728 and POCI-01-0145-FEDER - 007265. SFRH/BD/140829/2018. SFRH/BPD/124612/2016.",
year = "2019",
month = "1",
day = "1",
doi = "10.1080/00914037.2019.1695205",
language = "English",
journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",
issn = "0091-4037",
publisher = "Taylor & Francis",

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T1 - Cation-mediated gelation of the fucose-rich polysaccharide FucoPol: preparation and characterization of hydrogel beads and their cytotoxicity assessment

AU - Fialho, Letícia

AU - Araújo, Diana

AU - Alves, Vitor D.

AU - Roma-Rodrigues, Catarina

AU - Baptista, Pedro V.

AU - Fernandes, Alexandra R.

AU - Freitas, Filomena

AU - Reis, Maria A. M.

N1 - FCT/MEC (UID/Multi/04378/2019). PEst-OE/AGR/UI0245/2014. POCI-01-0145-FEDER-007728 and POCI-01-0145-FEDER - 007265. SFRH/BD/140829/2018. SFRH/BPD/124612/2016.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - This study describes for the first time the iron- and copper-mediated gelation of FucoPol, fucose-rich bacterial polysaccharide. The ability of FucoPol to gel in the presence of metal cations, including iron(III) and copper(II), was used for the preparation of hydrogel beads. Iron mediated the formation of stable and not cytotoxic gel beads, while copper resulted in fragile and cytotoxic ones. Copper-mediated beads coated with an iron-mediated gel layer were more stable and had reduced cytotoxicity. The resulting polymeric structures had differing morphology, physical properties and cytotoxicity, which support their use in several applications, including biomedicine, agriculture and bioremediation.

AB - This study describes for the first time the iron- and copper-mediated gelation of FucoPol, fucose-rich bacterial polysaccharide. The ability of FucoPol to gel in the presence of metal cations, including iron(III) and copper(II), was used for the preparation of hydrogel beads. Iron mediated the formation of stable and not cytotoxic gel beads, while copper resulted in fragile and cytotoxic ones. Copper-mediated beads coated with an iron-mediated gel layer were more stable and had reduced cytotoxicity. The resulting polymeric structures had differing morphology, physical properties and cytotoxicity, which support their use in several applications, including biomedicine, agriculture and bioremediation.

KW - cytotoxicity

KW - FucoPol

KW - hydrogel beads

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M3 - Article

JO - International Journal of Polymeric Materials and Polymeric Biomaterials

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SN - 0091-4037

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