Abstract

Catechols from abietic acid were prepared by a short and good yielding chemical process and further evaluated for several biological activities namely, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative and inhibition of nitric oxide. Their properties were compared with those of carnosic acid (6), a naturally occurring catechol with an abietane skeleton and known to possess potent antioxidant activity, as well as anticancer and antiviral properties. From all the synthetic catechols tested compound 2 showed the best activities, stronger than carnosic acid.
Original languageUnknown
Pages (from-to)1631-1638
JournalBioorganic & Medicinal Chemistry
Volume11
Issue number8
DOIs
Publication statusPublished - 1 Jan 2003

Cite this

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title = "Catechols from abietic acid: Synthesis and evaluation as bioactive compounds",
abstract = "Catechols from abietic acid were prepared by a short and good yielding chemical process and further evaluated for several biological activities namely, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative and inhibition of nitric oxide. Their properties were compared with those of carnosic acid (6), a naturally occurring catechol with an abietane skeleton and known to possess potent antioxidant activity, as well as anticancer and antiviral properties. From all the synthetic catechols tested compound 2 showed the best activities, stronger than carnosic acid.",
keywords = "ANTIOXIDANTS, carnosic acid, antioxidant, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative, ROSEMARY, SWINE FEVER VIRUS, BRONCHIAL CELLS, MUTAGENICITY, ASSAY",
author = "Duarte, {Maria Paula Amaro de Castilho} and Laires, {Ant{\'o}nio Jos{\'e} Cabrita Lucas} and J. Rueff",
note = "PMID:12659748 WOS:000181996100004",
year = "2003",
month = "1",
day = "1",
doi = "10.1016/S0968-0896(03)00063-4",
language = "Unknown",
volume = "11",
pages = "1631--1638",
journal = "Bioorganic & Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Science B.V., Amsterdam.",
number = "8",

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TY - JOUR

T1 - Catechols from abietic acid: Synthesis and evaluation as bioactive compounds

AU - Duarte, Maria Paula Amaro de Castilho

AU - Laires, António José Cabrita Lucas

AU - Rueff, J.

N1 - PMID:12659748 WOS:000181996100004

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Catechols from abietic acid were prepared by a short and good yielding chemical process and further evaluated for several biological activities namely, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative and inhibition of nitric oxide. Their properties were compared with those of carnosic acid (6), a naturally occurring catechol with an abietane skeleton and known to possess potent antioxidant activity, as well as anticancer and antiviral properties. From all the synthetic catechols tested compound 2 showed the best activities, stronger than carnosic acid.

AB - Catechols from abietic acid were prepared by a short and good yielding chemical process and further evaluated for several biological activities namely, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative and inhibition of nitric oxide. Their properties were compared with those of carnosic acid (6), a naturally occurring catechol with an abietane skeleton and known to possess potent antioxidant activity, as well as anticancer and antiviral properties. From all the synthetic catechols tested compound 2 showed the best activities, stronger than carnosic acid.

KW - ANTIOXIDANTS

KW - carnosic acid, antioxidant, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative

KW - ROSEMARY

KW - SWINE FEVER VIRUS

KW - BRONCHIAL CELLS

KW - MUTAGENICITY

KW - ASSAY

U2 - 10.1016/S0968-0896(03)00063-4

DO - 10.1016/S0968-0896(03)00063-4

M3 - Article

VL - 11

SP - 1631

EP - 1638

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

SN - 0968-0896

IS - 8

ER -