Carriage of multiple Streptococcus pneumoniae capsular types is frequent among children with invasive pneumococcal disease

Sofia Félix, Desirée Henares, Carmen Muñoz-Almagro, Raquel Sá-Leão

Research output: Contribution to journalArticlepeer-review

Abstract

Streptococcus pneumoniae (pneumococcus) is a human pathogen that colonizes the nasopharynx. We investigated serotype distribution in paired invasive and nasopharyngeal samples obtained from 57 children during invasive pneumococcal disease. Of 39 nasopharyngeal samples positive for pneumococci, 46.2% contained a serotype different from the one causing disease. This study reports a high frequency of pneumococcal multiple serotype carriage in children with invasive pneumococcal disease. Whether multiple serotype carriage is important for the onset and progress to pneumococcal infection warrants further investigation.

Original languageEnglish
Pages (from-to)2397-2401
Number of pages5
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume40
Issue number11
DOIs
Publication statusPublished - Nov 2021

Keywords

  • Children
  • Co-colonization
  • Invasive pneumococcal disease
  • Multiple serotype carriage
  • Streptococcus pneumoniae

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