Carriage of internationally spread clones of Streptococcus pneumoniae with unusual drug resistance patterns in children attending day care centers in Lisbon, Portugal

Raquel Sá-Leão, Alexander Tomasz, Ilda Santos Sanches, António Brito-Avô, Sigurdur E. Vilhelmsson, Karl G. Kristinsson, Herminia De Lencastre

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Over half (259/503) of drug-resistant (DR) pneumococci colonizing healthy children attending day care centers in Lisbon were identified by molecular typing methods as representatives of several internationally spread clones. These included the 2 penicillin-resistant pandemic Spanish/USA and French/Spanish clones (21% of all DR pneumococci) and 5 new lineages with unusual antibiotypes (accounting for an additional 30% of all DR pneumococci). The most characteristic feature of the latter group was the high frequency of resistance to macrolides and tetracycline and very low or no resistance to penicillin. These observations provide support for the notion that the nasopharyngeal flora of children in day care centers may be a global reservoir of worldwide prevalent strains of DR pneumococci.

Original languageEnglish
Pages (from-to)1153-1160
Number of pages8
JournalJournal of Infectious Diseases
Volume182
Issue number4
DOIs
Publication statusPublished - 2000

Keywords

  • penicillin
  • drug resistance
  • child
  • clone cells
  • day care
  • disease transmission
  • penicillin resistance
  • pneumococcal infections
  • portugal
  • macrolides
  • streptococcus pneumoniae
  • tetracycline
  • well child
  • pandemics
  • microbial colonization

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