C-reactive protein (CRP) is an acute phase protein that plays a major role in the regulation of the inflammatory response. It activates the classical complement pathway in a controlled fashion, enhancing the capacity for defence against bacterial infections. It promotes the regulation of M Phi activity through Fc gamma R, and is associated with the clearance of apo cells and nuclear antigen, thus becoming a protective molecule against pathogenic autoimmune responses in general, and systemic lupus erythematosus in particular. CRP is also associated with atherosclerosis, both in the general population and in different auto-immune conditions. It plays a double role as a biomarker for vascular risk and as an independent risk factor as it can also perpetuate the inflammatory response. Its multi-task behaviour makes it a pivotal structure both in the comprehension of the pathogenesis of auto-immune and inflammatory responses as well as an important tool in the clinical management of patients.