Abstract
Objective: To assess repeatability and reproducibility of spirometry measurements, and bronchodilator responsiveness (BDR), in healthy 3-6-year-old preschool children and those with asthma. Design: Spirometry was performed before and 20 minutes after administering either inhaled placebo (for repeatability) or 400 μg salbutamol (for BDR) on two separate occasions (reproducibility) 3-23 days apart in asthmatic preschoolers and healthy controls. Settings: Lung Function Laboratory, Hospital de Dona Estefania, Lisbon. Participants: Healthy preschool children and those with physician-diagnosed asthma, recruited from local Health Clinics and Outpatient Clinic. Main outcome measures: Paired measurements of forced expired volume in 0.75 s (FEV0.75) and forced mid-expiratory flows (FEF 25-75). Results: Technically successful baseline results were obtained in 86% of children assessed. Paired data were obtained in 43 asthmatic and 22 controls (median (range) age: 5.1 (3.4-6.8) years). Baseline FEV 0.75 was significantly lower in asthmatic children (mean (SD): 90 (15)% predicted) than in controls (102 (13) % predicted; p<0.001). Within-occasion coefficient of repeatability following placebo was similar in both groups, being 10.4% in asthma and 13.2% in controls for FEV0.75. Following bronchodilator, FEV0.75 increased significantly more in asthmatic preschoolers (mean (SD): 15.0 (12) %) than in controls (4.5 (5) %; p<0.001), with no significant difference between groups post-bronchodilator. Between-occasion variability was similar to within-day repeatability in controls, but almost twice as high in asthmatic children. Conclusions: BDR can be assessed reliably using FEV0.75 in wheezy preschoolers, provided within-subject variability and responsiveness in health are taken into consideration.
| Original language | English |
|---|---|
| Pages (from-to) | 112-117 |
| Number of pages | 6 |
| Journal | Archives of Disease in Childhood |
| Volume | 98 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Feb 2013 |
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Bronchodilator responsiveness using spirometry in healthy and asthmatic preschool children. / Borrego, Luis Miguel; Stocks, Janet; Almeida, Isabel; Stanojevic, Sanja; Antunes, João; Leiria-Pinto, Paula; Rosado-Pinto, José E.; Hoo, Ah Fong.
In: Archives of Disease in Childhood, Vol. 98, No. 2, 01.02.2013, p. 112-117.Research output: Contribution to journal › Article
TY - JOUR
T1 - Bronchodilator responsiveness using spirometry in healthy and asthmatic preschool children
AU - Borrego, Luis Miguel
AU - Stocks, Janet
AU - Almeida, Isabel
AU - Stanojevic, Sanja
AU - Antunes, João
AU - Leiria-Pinto, Paula
AU - Rosado-Pinto, José E.
AU - Hoo, Ah Fong
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Objective: To assess repeatability and reproducibility of spirometry measurements, and bronchodilator responsiveness (BDR), in healthy 3-6-year-old preschool children and those with asthma. Design: Spirometry was performed before and 20 minutes after administering either inhaled placebo (for repeatability) or 400 μg salbutamol (for BDR) on two separate occasions (reproducibility) 3-23 days apart in asthmatic preschoolers and healthy controls. Settings: Lung Function Laboratory, Hospital de Dona Estefania, Lisbon. Participants: Healthy preschool children and those with physician-diagnosed asthma, recruited from local Health Clinics and Outpatient Clinic. Main outcome measures: Paired measurements of forced expired volume in 0.75 s (FEV0.75) and forced mid-expiratory flows (FEF 25-75). Results: Technically successful baseline results were obtained in 86% of children assessed. Paired data were obtained in 43 asthmatic and 22 controls (median (range) age: 5.1 (3.4-6.8) years). Baseline FEV 0.75 was significantly lower in asthmatic children (mean (SD): 90 (15)% predicted) than in controls (102 (13) % predicted; p<0.001). Within-occasion coefficient of repeatability following placebo was similar in both groups, being 10.4% in asthma and 13.2% in controls for FEV0.75. Following bronchodilator, FEV0.75 increased significantly more in asthmatic preschoolers (mean (SD): 15.0 (12) %) than in controls (4.5 (5) %; p<0.001), with no significant difference between groups post-bronchodilator. Between-occasion variability was similar to within-day repeatability in controls, but almost twice as high in asthmatic children. Conclusions: BDR can be assessed reliably using FEV0.75 in wheezy preschoolers, provided within-subject variability and responsiveness in health are taken into consideration.
AB - Objective: To assess repeatability and reproducibility of spirometry measurements, and bronchodilator responsiveness (BDR), in healthy 3-6-year-old preschool children and those with asthma. Design: Spirometry was performed before and 20 minutes after administering either inhaled placebo (for repeatability) or 400 μg salbutamol (for BDR) on two separate occasions (reproducibility) 3-23 days apart in asthmatic preschoolers and healthy controls. Settings: Lung Function Laboratory, Hospital de Dona Estefania, Lisbon. Participants: Healthy preschool children and those with physician-diagnosed asthma, recruited from local Health Clinics and Outpatient Clinic. Main outcome measures: Paired measurements of forced expired volume in 0.75 s (FEV0.75) and forced mid-expiratory flows (FEF 25-75). Results: Technically successful baseline results were obtained in 86% of children assessed. Paired data were obtained in 43 asthmatic and 22 controls (median (range) age: 5.1 (3.4-6.8) years). Baseline FEV 0.75 was significantly lower in asthmatic children (mean (SD): 90 (15)% predicted) than in controls (102 (13) % predicted; p<0.001). Within-occasion coefficient of repeatability following placebo was similar in both groups, being 10.4% in asthma and 13.2% in controls for FEV0.75. Following bronchodilator, FEV0.75 increased significantly more in asthmatic preschoolers (mean (SD): 15.0 (12) %) than in controls (4.5 (5) %; p<0.001), with no significant difference between groups post-bronchodilator. Between-occasion variability was similar to within-day repeatability in controls, but almost twice as high in asthmatic children. Conclusions: BDR can be assessed reliably using FEV0.75 in wheezy preschoolers, provided within-subject variability and responsiveness in health are taken into consideration.
UR - http://www.scopus.com/inward/record.url?scp=84872678205&partnerID=8YFLogxK
U2 - 10.1136/archdischild-2012-301819
DO - 10.1136/archdischild-2012-301819
M3 - Article
VL - 98
SP - 112
EP - 117
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
SN - 0003-9888
IS - 2
ER -