TY - JOUR
T1 - Breath volatile organic compounds (VOCs) as biomarkers for the diagnosis of pathological conditions
T2 - A review
AU - Moura, Pedro Catalão
AU - Raposo, Maria
AU - Vassilenko, Valentina
N1 - Funding Information:
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04559%2F2020/PT#
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04559%2F2020/PT#
info:eu-repo/grantAgreement/FCT/OE/PD%2FBDE%2F150627%2F2020/PT#
Publisher Copyright:
© 2023 The Authors
PY - 2023/8
Y1 - 2023/8
N2 - Normal and abnormal/pathological status of physiological processes in the human organism can be characterized through Volatile Organic Compounds (VOCs) emitted in breath. Recently, a wide range of volatile analytes has risen as biomarkers. These compounds have been addressed in the scientific and medical communities as an extremely valuable metabolic window. Once collected and analysed, VOCs can represent a tool for a rapid, accurate, non-invasive, and painless diagnosis of several diseases and health conditions. These biomarkers are released by exhaled breath, urine, faeces, skin, and several other ways, at trace concentration levels, usually in the ppbv (μg/L) range. For this reason, the analytical techniques applied for detecting and clinically exploiting the VOCs are extremely important. The present work reviews the most promising results in the field of breath biomarkers and the most common methods of detection of VOCs. A total of 16 pathologies and the respective database of compounds are addressed. An updated version of the VOCs biomarkers database can be consulted at: https://neomeditec.com/VOCdatabase/
AB - Normal and abnormal/pathological status of physiological processes in the human organism can be characterized through Volatile Organic Compounds (VOCs) emitted in breath. Recently, a wide range of volatile analytes has risen as biomarkers. These compounds have been addressed in the scientific and medical communities as an extremely valuable metabolic window. Once collected and analysed, VOCs can represent a tool for a rapid, accurate, non-invasive, and painless diagnosis of several diseases and health conditions. These biomarkers are released by exhaled breath, urine, faeces, skin, and several other ways, at trace concentration levels, usually in the ppbv (μg/L) range. For this reason, the analytical techniques applied for detecting and clinically exploiting the VOCs are extremely important. The present work reviews the most promising results in the field of breath biomarkers and the most common methods of detection of VOCs. A total of 16 pathologies and the respective database of compounds are addressed. An updated version of the VOCs biomarkers database can be consulted at: https://neomeditec.com/VOCdatabase/
KW - Biomarkers
KW - Breath sampling
KW - Exhaled breath
KW - VOCs
KW - Volatile organic compounds
UR - http://www.scopus.com/inward/record.url?scp=85165277465&partnerID=8YFLogxK
U2 - 10.1016/j.bj.2023.100623
DO - 10.1016/j.bj.2023.100623
M3 - Review article
C2 - 37336362
AN - SCOPUS:85165277465
SN - 2319-4170
VL - 46
JO - Biomedical Journal
JF - Biomedical Journal
IS - 4
M1 - 100623
ER -