Bone Diagenesis and its Implication for Disease Diagnosis

The Relevance of Bone Microstructure Analysis for the Study of Past Human Remains

Sandra Assis, Anne Keenleyside, Ana Luisa Santos, Francisca Alves Cardoso

Research output: Contribution to journalArticle

7 Citations (Scopus)
12 Downloads (Pure)

Abstract

When bone is exposed to the burial environment it may experience structural changes induced by multiple agents. The study of postmortem alterations is important to differentiate decomposition phenomena from normal physiological processes or pathological lesions, as well as to assess bone tissue quality. Microscopy is of great utility to evaluate the integrity of bone microstructure and it provides significant data on long-term bone decomposition. A total of 18 human bone sections (eight archeological and ten retrieved from an identified skeletal collection) were selected for analysis under plane light and polarized light. The aim of this exploratory study was to analyze the impact of diagenesis and taphonomy on the bone microstructure, as well as on the differential diagnosis of pathological conditions. The results showed that the microscopy approach to bone tissues contributed materially as an aid in the detailed description of the main diagenetic changes observed. It showed that gross inspection does not provide a realistic assessment of bone tissue preservation, which can impact in the characterization of lesions present and subsequent disease diagnosis. Therefore, researchers should continue to consider the application of histological techniques if the aim is to comprehend tissue integrity and its association with decomposition or disease.

Original languageEnglish
Pages (from-to)805-825
Number of pages21
JournalMicroscopy and Microanalysis
Volume21
Issue number4
DOIs
Publication statusPublished - Aug 2015

Keywords

  • Burial environment
  • Taphonomy
  • Microscopy
  • Bone tissue preservation
  • Paleopathology
  • Archaelogical bone
  • Ancient bone
  • Preservation
  • Carcinoma
  • Identification
  • Destruction
  • Portugal
  • Site
  • DNA

Cite this

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title = "Bone Diagenesis and its Implication for Disease Diagnosis: The Relevance of Bone Microstructure Analysis for the Study of Past Human Remains",
abstract = "When bone is exposed to the burial environment it may experience structural changes induced by multiple agents. The study of postmortem alterations is important to differentiate decomposition phenomena from normal physiological processes or pathological lesions, as well as to assess bone tissue quality. Microscopy is of great utility to evaluate the integrity of bone microstructure and it provides significant data on long-term bone decomposition. A total of 18 human bone sections (eight archeological and ten retrieved from an identified skeletal collection) were selected for analysis under plane light and polarized light. The aim of this exploratory study was to analyze the impact of diagenesis and taphonomy on the bone microstructure, as well as on the differential diagnosis of pathological conditions. The results showed that the microscopy approach to bone tissues contributed materially as an aid in the detailed description of the main diagenetic changes observed. It showed that gross inspection does not provide a realistic assessment of bone tissue preservation, which can impact in the characterization of lesions present and subsequent disease diagnosis. Therefore, researchers should continue to consider the application of histological techniques if the aim is to comprehend tissue integrity and its association with decomposition or disease.",
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Bone Diagenesis and its Implication for Disease Diagnosis : The Relevance of Bone Microstructure Analysis for the Study of Past Human Remains. / Assis, Sandra; Keenleyside, Anne; Santos, Ana Luisa; Cardoso, Francisca Alves.

In: Microscopy and Microanalysis, Vol. 21, No. 4, 08.2015, p. 805-825.

Research output: Contribution to journalArticle

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AU - Assis, Sandra

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KW - Identification

KW - Destruction

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KW - Site

KW - DNA

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