Bone biopsy practice patterns across Europe: The European renal osteodystrophy initiative - A position paper

P. Evenepoel, P. D'Haese, J. Bacchetta, J. Cannata-Andia, A. Ferreira, M. Haarhaus, S. Mazzaferro, M.-H. Lafage Proust, S. Salam, G. Spasovski, M. Cozzolino

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

Renal osteodystrophy (ROD) is a heterogeneous group of metabolic bone diseases complicating progressive chronic kidney disease (CKD). Bone biomarkers and bone imaging techniques may help to assess bone health and predict fractures in CKD but do have important inherent limitations. By informing on bone turnover and mineralization, a bone biopsy may help to guide prevention and treatment of ROD and its consequences. According to a recent survey conducted among European nephrologists, bone biopsies are performed rather exceptionally, both for clinical and research purposes. Obviously, clinical research in the field of ROD is threatened by vanishing clinical and pathological expertise, small patient cohorts and scientific isolation. In March 2016, the European Renal Osteodystrophy (EU-ROD) initiative was created under the umbrella of the ERA-EDTA CKD-mineral and bone disorder (MBD) Working Group to revitalize bone biopsy as a clinically useful tool in the diagnostic workup of CKD-MBD and to foster research on the epidemiology, implications and reversibility of ROD. As such, the EU-ROD initiative aims to increase the understanding of ROD and ultimately to improve outcomes in CKD patients. © The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
Original languageEnglish
Pages (from-to)1608-1613
Number of pages6
JournalNephrology Dialysis Transplantation
Volume32
Issue number10
DOIs
Publication statusPublished - Oct 2017

Keywords

  • biomarkers
  • bone mineral density
  • chronic renal failure
  • hyperparathyroidism
  • renal osteodystrophy

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