Bis(o-methylserotonin)-containing iridium(III) and ruthenium(II) complexes as new cellular imaging dyes: Synthesis, applications, and photophysical and computational studies

Cristina Núñez, C. Silva López, Olalla Nieto Faza, J. Fernández-Lodeiro, M. Diniz, Rufina Bastida, J. L. Capelo, C. Lodeiro

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

We report the synthesis, characterization, and scope of a new versatile emissive molecular probe functionalized with a 1,10-phenanthroline moiety containing methylserotonin groups as binding sites for metal ion recognition. The synthesis, characterization, and evaluation of the in vitro imaging capability of the iridium(III) and ruthenium(II) complexes [Ir(ppy)2(N-N)](+) and [Ru(bpy)2(N-N)](2+), in which ppyis 2-phenylpyridine, bpyis 2,2'-bipyridine, and N-N is a 1,10-phenanthroline ligand functionalized with two methylserotonin groups to serve as binding sites for metal ion recognition, is reported. The uptake of these compounds by living freshwater fish (Carassius auratus) was studied by fluorescence microscopy, and the cytotoxicity of ligand N-N and [Ru(bpy)2(N-N)](2+) in this species was also investigated.
Original languageEnglish
Pages (from-to)679-692
Number of pages14
JournalJournal Of Biological Inorganic Chemistry
Volume18
Issue number6
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Cellular imaging
  • Cyclometalated complexes
  • Dyes
  • Serotonin
  • Time-dependent density functional theory
  • bis(o methylserotonin)
  • fluorescent dye
  • iridium complex
  • ruthenium complex
  • unclassified drug
  • animal cell
  • animal experiment
  • animal tissue
  • article
  • binding site
  • chemical structure
  • complex formation
  • controlled study
  • cytotoxicity test
  • erythrocyte
  • fluorescence microscopy
  • goldfish
  • ligand binding
  • molecular imaging
  • molecular probe
  • molecular recognition
  • molecular stability
  • nonhuman
  • photochemical quenching
  • physical chemistry
  • priority journal
  • Carassius auratus
  • Animals
  • Fluorescent Dyes
  • Goldfish
  • Iridium
  • Microscopy, Fluorescence
  • Models, Biological
  • Models, Molecular
  • Molecular Structure
  • Organometallic Compounds
  • Photochemical Processes
  • Quantum Theory
  • Ruthenium
  • Tissue Distribution

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