Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases

Regina Menezes, Alexandre Foito, Carolina Jardim, Inês Costa, Gonçalo Garcia, Rita Rosado-Ramos, Sabine Freitag, Colin James Alexander, Tiago Fleming Outeiro, Derek Stewart, Cláudia N Santos

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Abstract

Plants are a reservoir of high-value molecules with underexplored biomedical applications. With the aim of identifying novel health-promoting attributes in underexplored natural sources, we scrutinized the diversity of (poly)phenols present within the berries of selected germplasm from cultivated, wild, and underutilized Rubus species. Our strategy combined the application of metabolomics, statistical analysis, and evaluation of (poly)phenols' bioactivity using a yeast-based discovery platform. We identified species as sources of (poly)phenols interfering with pathological processes associated with redox-related diseases, particularly, amyotrophic lateral sclerosis, cancer, and inflammation. In silico prediction of putative bioactives suggested cyanidin-hexoside as an anti-inflammatory molecule which was validated in yeast and mammalian cells. Moreover, cellular assays revealed that the cyanidin moiety was responsible for the anti-inflammatory properties of cyanidin-hexoside. Our findings unveiled novel (poly)phenolic bioactivities and illustrated the power of our integrative approach for the identification of dietary (poly)phenols with potential biomedical applications.

Original languageEnglish
Article number789
Pages (from-to)1-24
JournalAntioxidants
Volume9
Issue number9
DOIs
Publication statusPublished - Sep 2020

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