Bioproduction of gold nanoparticles for photothermal therapy

Catarina Oliveira Silva, Patrícia Rijo, Jesús Molpeceres, Lia Ascensão, Amílcar Roberto, Ana Sofia Fernandes, Ricardo Gomes, João M Pinto Coelho, Ana Gabriel, Pedro Vieira, Catarina Pinto Reis

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Photothermal response of plasmonic nanomaterials can be utilized for a number of therapeutic applications such as the ablation of solid tumors. Methods & results: Gold nanoparticles were prepared using different methods. After optimization, we applied an aqueous plant extract as the reducing and capping agent of gold and maximized the near-infrared absorption (650-900 nm). Resultant nanoparticles showed good biocompatibility when tested in vitro in human keratinocytes and yeast Saccharomyces cerevisiae. Gold nanoparticles were easily activated by controlled temperature with an ultrasonic water bath and application of a pulsed laser. Conclusion: These gold nanoparticles can be synthesized with reproducibility, modified with seemingly limitless chemical functional groups, with adequate controlled optical properties for laser phototherapy of tumors and targeted drug delivery.

Original languageEnglish
Pages (from-to)287-304
Number of pages18
JournalTherapeutic Delivery
Volume7
Issue number5
DOIs
Publication statusPublished - May 2016

Keywords

  • bioproduction
  • gold nanoparticles
  • photothermal therapy

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    Silva, C. O., Rijo, P., Molpeceres, J., Ascensão, L., Roberto, A., Fernandes, A. S., ... Reis, C. P. (2016). Bioproduction of gold nanoparticles for photothermal therapy. Therapeutic Delivery, 7(5), 287-304. https://doi.org/10.4155/tde-2015-0011