Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants

Sepehr Talebian, Bárbara Mendes, João Conniot, Syamak Farajikhah, Fariba Dehghani, Zhongyan Li, Diogo Bitoque, Gabriela Silva, Sina Naficy, João Conde, Gordon G. Wallace

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)
29 Downloads (Pure)

Abstract

The deployment of structures that enable localized release of bioactive molecules can result in more efficacious treatment of disease and better integration of implantable bionic devices. The strategic design of a biopolymeric coating can be used to engineer the optimal release profile depending on the task at hand. As illustrative examples, here advances in delivery of drugs from bone, brain, ocular, and cardiovascular implants are reviewed. These areas are focused to highlight that both hard and soft tissue implants can benefit from controlled localized delivery. The composition of biopolymers used to achieve appropriate delivery to the selected tissue types, and their corresponding outcomes are brought to the fore. To conclude, key factors in designing drug-loaded biopolymeric coatings for biomedical implants are highlighted.

Original languageEnglish
Article number2207603
JournalAdvanced Science
Volume10
Issue number12
Early online date2023
DOIs
Publication statusPublished - 26 Apr 2023

Keywords

  • biopolymers
  • controlled release
  • drug delivery
  • medical Implants

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