Biomimetic Heterostructures for Radiation Damage Studies

Maria de Fátima Guerreiro da Silva Campos Raposo, Paulo J. Gomes, João M.C. Lourenço, Margarida Coelho, S. V. Hoffmann, Ana Maria Botelho Do Rego, Robert W. McCullough, Nigel J. Mason, C. Lage, Paulo Manuel Assis Loureiro Limão-vieira, Paulo António Martins Ferreira Ribeiro

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The present work describes a methodology that can be used for the creation of biomimetic membranes based in sequential assembling of biological molecules, to be used for radiation damage studies in an environment mimicking, that of bio-systems. The major features of the method, the so called layer-by-layer technique, as well as the experimental parameters to take into account for heterostructures production are summarized here. Results for radiation damage in DNA containing biomimetic membranes prepared from different conditions methods revealed that the radiation induced damage is dependent on the heterostructure molecular composition, proving that the environment is of extreme importance for the extent of radiation induced damage in biological molecules.
Original languageEnglish
Title of host publicationBiomimetic Heterostructures for Radiation Damage Studies
Pages125-131
Number of pages7
DOIs
Publication statusPublished - 1 Jan 2008
EventRadam 2008 -
Duration: 1 Jan 2008 → …

Conference

ConferenceRadam 2008
Period1/01/08 → …

Keywords

  • Radiation damage and effects of ionizing radiation on biological systems
  • Biomimetic membranes
  • Layer-by-layer films
  • Physical radiation effects

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