Biomimetic Heterostructures for Radiation Damage Studies

Maria de Fátima Guerreiro da Silva Campos Raposo; Paulo J. Gomes; João M.C. Lourenço; Margarida Coelho; S. V. Hoffmann; Ana Maria Botelho Do Rego; Robert W. McCullough; Nigel J. Mason; C. Lage; Paulo Manuel Assis Loureiro Limão-vieira; Paulo António Martins Ferreira Ribeiro

doi:10.1063/1.3058971

Biomimetic Heterostructures for Radiation Damage Studies

Maria de Fátima Guerreiro da Silva Campos Raposo, Paulo J. Gomes, João M.C. Lourenço, Margarida Coelho, S. V. Hoffmann, Ana Maria Botelho Do Rego, Robert W. McCullough, Nigel J. Mason, C. Lage, Paulo Manuel Assis Loureiro Limão-vieira, Paulo António Martins Ferreira Ribeiro

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Citations (Scopus)

Abstract

The present work describes a methodology that can be used for the creation of biomimetic membranes based in sequential assembling of biological molecules, to be used for radiation damage studies in an environment mimicking, that of bio-systems. The major features of the method, the so called layer-by-layer technique, as well as the experimental parameters to take into account for heterostructures production are summarized here. Results for radiation damage in DNA containing biomimetic membranes prepared from different conditions methods revealed that the radiation induced damage is dependent on the heterostructure molecular composition, proving that the environment is of extreme importance for the extent of radiation induced damage in biological molecules.

Original language	English
Title of host publication	Biomimetic Heterostructures for Radiation Damage Studies
Pages	125-131
Number of pages	7
DOIs	https://doi.org/10.1063/1.3058971
Publication status	Published - 1 Jan 2008
Event	Radam 2008 - Duration: 1 Jan 2008 → …

Conference

Conference	Radam 2008
Period	1/01/08 → …

Keywords

Radiation damage and effects of ionizing radiation on biological systems
Biomimetic membranes
Layer-by-layer films
Physical radiation effects

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10.1063/1.3058971

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Raposo, M. D. F. G. D. S. C., Gomes, P. J., Lourenço, J. M. C., Coelho, M., Hoffmann, S. V., Do Rego, A. M. B., McCullough, R. W., Mason, N. J., Lage, C., Limão-vieira, P. M. A. L., & Ribeiro, P. A. M. F. (2008). Biomimetic Heterostructures for Radiation Damage Studies. In Biomimetic Heterostructures for Radiation Damage Studies (pp. 125-131) https://doi.org/10.1063/1.3058971

@inproceedings{599db5eb435d42fabe62fa66648c1ca9,

title = "Biomimetic Heterostructures for Radiation Damage Studies",

abstract = "The present work describes a methodology that can be used for the creation of biomimetic membranes based in sequential assembling of biological molecules, to be used for radiation damage studies in an environment mimicking, that of bio-systems. The major features of the method, the so called layer-by-layer technique, as well as the experimental parameters to take into account for heterostructures production are summarized here. Results for radiation damage in DNA containing biomimetic membranes prepared from different conditions methods revealed that the radiation induced damage is dependent on the heterostructure molecular composition, proving that the environment is of extreme importance for the extent of radiation induced damage in biological molecules.",

keywords = "POLYELECTROLYTE, ADSORPTION, POLY(O-METHOXYANILINE), STRAND BREAKS, COATINGS, DNA, LAYER-BY-LAYER FILMS, EV ELECTRONS, COUNTERIONS, MECHANISMS, Radiation damage and effects of ionizing radiation on biological systems, Biomimetic membranes, Layer-by-layer films, Physical radiation effects",

author = "Raposo, {Maria de F{\'a}tima Guerreiro da Silva Campos} and Gomes, {Paulo J.} and Louren{\c c}o, {Jo{\~a}o M.C.} and Margarida Coelho and Hoffmann, {S. V.} and {Do Rego}, {Ana Maria Botelho} and McCullough, {Robert W.} and Mason, {Nigel J.} and C. Lage and Lim{\~a}o-vieira, {Paulo Manuel Assis Loureiro} and Ribeiro, {Paulo Ant{\'o}nio Martins Ferreira}",

year = "2008",

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doi = "10.1063/1.3058971",

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AU - Lourenço, João M.C.

AU - Coelho, Margarida

AU - Hoffmann, S. V.

AU - Do Rego, Ana Maria Botelho

AU - McCullough, Robert W.

AU - Mason, Nigel J.

AU - Lage, C.

AU - Limão-vieira, Paulo Manuel Assis Loureiro

AU - Ribeiro, Paulo António Martins Ferreira

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N2 - The present work describes a methodology that can be used for the creation of biomimetic membranes based in sequential assembling of biological molecules, to be used for radiation damage studies in an environment mimicking, that of bio-systems. The major features of the method, the so called layer-by-layer technique, as well as the experimental parameters to take into account for heterostructures production are summarized here. Results for radiation damage in DNA containing biomimetic membranes prepared from different conditions methods revealed that the radiation induced damage is dependent on the heterostructure molecular composition, proving that the environment is of extreme importance for the extent of radiation induced damage in biological molecules.

AB - The present work describes a methodology that can be used for the creation of biomimetic membranes based in sequential assembling of biological molecules, to be used for radiation damage studies in an environment mimicking, that of bio-systems. The major features of the method, the so called layer-by-layer technique, as well as the experimental parameters to take into account for heterostructures production are summarized here. Results for radiation damage in DNA containing biomimetic membranes prepared from different conditions methods revealed that the radiation induced damage is dependent on the heterostructure molecular composition, proving that the environment is of extreme importance for the extent of radiation induced damage in biological molecules.

KW - POLYELECTROLYTE

KW - ADSORPTION

KW - POLY(O-METHOXYANILINE)

KW - STRAND BREAKS

KW - COATINGS

KW - DNA

KW - LAYER-BY-LAYER FILMS

KW - EV ELECTRONS

KW - COUNTERIONS

KW - MECHANISMS

KW - Radiation damage and effects of ionizing radiation on biological systems

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KW - Layer-by-layer films

KW - Physical radiation effects

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U2 - 10.1063/1.3058971

DO - 10.1063/1.3058971

M3 - Conference contribution

SN - 978-0-7354-0611-7

SP - 125

EP - 131

BT - Biomimetic Heterostructures for Radiation Damage Studies

T2 - Radam 2008

Y2 - 1 January 2008

ER -

Biomimetic Heterostructures for Radiation Damage Studies

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