Bioinspired and biomimetic cancer-cell-derived membrane nanovesicles for preclinical tumor-targeted nanotheranostics

Rajendra Prasad, Bárbara B. Mendes, Mahadeo Gorain, Gopal Chandra Kundu, Narendra Gupta, Berney Peng, Eaint Honey Aung Win, He Qing, João Conde

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
15 Downloads (Pure)

Abstract

Bioinspired cell-membrane-camouflaged nanohybrids have been proposed to enhance tumor targeting by harnessing their immune escape and self-recognition abilities. In this study, we introduce cancer-cell-derived membrane nanovesicles (CCMVs) integrated with gold nanorods (AuVNRs) in addition to therapeutic and imaging cargos such as doxorubicin and indocyanine green. This approach enhances targeted tumor imaging and enables synergistic chemo-phototherapeutics for solid tumors. CCMVs demonstrate significant tumor penetration and retention, serving as nanotheranostics with accessible surface biomarkers, biomimicking properties, and homologous targeting abilities. By evading uptake by the mononuclear phagocytic system, CCMVs can diffuse into the deep tumor core, leading to precise tumor reduction while preserving the surrounding healthy tissues. Notably, intravenous administration of these theranostic agents ensures biocompatibility, as evidenced by a survival period of approximately two months (up to 63 days) without any observed side effects. Our findings underscore the diagnostic and therapeutic potential of this biomimetic nanotheranostics platform.

Original languageEnglish
Article number101648
JournalCell Reports Physical Science
Volume4
Issue number11
Early online date2023
DOIs
Publication statusPublished - 15 Nov 2023

Keywords

  • biomembrane-coated nanoparticles
  • breast cancer
  • cancer nanotherapy
  • homologous targeting
  • nanovesicles
  • synergistic therapeutics
  • theranostics

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