Biocompatible locust bean gum as mesoporous carriers for naproxen delivery

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The work reports the impregnation of naproxen into locust bean gum mesoporous matrixes with different textural properties. The matrixes were prepared through the dissolution of the biopolymer in water and in two ionic liquids (ILs): [bmim][Cl] and [C2OHmim][Cl] and dried with scCO2. The poor water-soluble pharmaceutical drug naproxen was loaded into the matrixes and the composites were characterized by attenuated total reflectance-Fourier transform infrared spectroscopy and by differential scanning calorimetry; the results were compared with neat ILs and drug. The naproxen release from the matrixes was attempted at pH 7.4. Sustained release of naproxen in the different composites occurs, and consequently the naproxen release has lower rates compared with neat crystalline naproxen dissolution. Nevertheless, it was possible to observe small differences on release profiles for the studied composites. The higher release rate was observed for the composite where [bmim][Cl] was used as solvent, for which the calorimetric analysis revealed full amorphization of the incorporated drug. Cytotoxicity assays reveal that cellular viability in Caco-2 cells is preserved. This fact allied with the biocompatibility of locust bean gum allow for the composites potential application as naproxen controlled/sustained delivery systems with higher drug bioavailability achieved through naproxen amorphization.

Original languageEnglish
Article number121973
JournalMaterials Chemistry And Physics
Volume239
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • Amorphous state
  • Drug loading
  • Drug release
  • DSC
  • Locust bean gum mesoporous matrixes

Fingerprint Dive into the research topics of 'Biocompatible locust bean gum as mesoporous carriers for naproxen delivery'. Together they form a unique fingerprint.

Cite this