TY - JOUR
T1 - Bioactivity, mechanical properties and drug delivery ability of bioactive glass-ceramic scaffolds coated with a natural-derived polymer
AU - Araújo, Marco F. A. S.
AU - Viveiros, Raquel
AU - Philippart, A.
AU - Miola, M.
AU - Doumett, S.
AU - Baldi, G.
AU - Pérez, Javier
AU - Boccaccini, A. R.
AU - Aguiar-Ricardo, Ana
AU - Verné, E.
N1 - Sem pdf conforme despacho.
European Union's Seventh Framework Programme (EU ITN FP-7) - GlaCERCo GA 264526 ;
Hovione - SFRH/BDE/51907/2012 ;
Hovione through LAQV-REQUIMTE - UID/QUI/50006/2013
PY - 2017/8/1
Y1 - 2017/8/1
N2 - In this work, hybrid melanin-coated bioactive glass-ceramic multifunctional scaffolds were developed and characterized in terms of mechanical strength, in vitro bioactivity in simulated body fluid (SBF) and ability to load ibuprofen. The coated scaffolds exhibited an accelerated bioactivity in comparison with the uncoated ones, being able of developing hydroxyapatite-like crystals after 7 days soaking in simulated body fluid (SBF). Besides its positive influence on the scaffolds bioactivity, the melanin coating was able to enhance their mechanical properties, increasing the initial compressive strength by a factor of > 2.5. Furthermore, ibuprofen was successfully loaded on this coating, allowing a controlled drug release of the anti-inflammatory agent.
AB - In this work, hybrid melanin-coated bioactive glass-ceramic multifunctional scaffolds were developed and characterized in terms of mechanical strength, in vitro bioactivity in simulated body fluid (SBF) and ability to load ibuprofen. The coated scaffolds exhibited an accelerated bioactivity in comparison with the uncoated ones, being able of developing hydroxyapatite-like crystals after 7 days soaking in simulated body fluid (SBF). Besides its positive influence on the scaffolds bioactivity, the melanin coating was able to enhance their mechanical properties, increasing the initial compressive strength by a factor of > 2.5. Furthermore, ibuprofen was successfully loaded on this coating, allowing a controlled drug release of the anti-inflammatory agent.
KW - Drug delivery
KW - Ibuprofen
KW - Mechanical properties
KW - Melanin
KW - Scaffolds
KW - Supercritical CO
UR - http://www.scopus.com/inward/record.url?scp=85016517078&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2017.03.169
DO - 10.1016/j.msec.2017.03.169
M3 - Article
C2 - 28532039
AN - SCOPUS:85016517078
SN - 0928-4931
VL - 77
SP - 342
EP - 351
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
ER -