Bioactivity, mechanical properties and drug delivery ability of bioactive glass-ceramic scaffolds coated with a natural-derived polymer

M. Araújo, R. Viveiros, A. Philippart, M. Miola, S. Doumett, G. Baldi, J. Perez, A. R. Boccaccini, A. Aguiar-Ricardo, E. Verné

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In this work, hybrid melanin-coated bioactive glass-ceramic multifunctional scaffolds were developed and characterized in terms of mechanical strength, in vitro bioactivity in simulated body fluid (SBF) and ability to load ibuprofen. The coated scaffolds exhibited an accelerated bioactivity in comparison with the uncoated ones, being able of developing hydroxyapatite-like crystals after 7 days soaking in simulated body fluid (SBF). Besides its positive influence on the scaffolds bioactivity, the melanin coating was able to enhance their mechanical properties, increasing the initial compressive strength by a factor of > 2.5. Furthermore, ibuprofen was successfully loaded on this coating, allowing a controlled drug release of the anti-inflammatory agent.

Original languageEnglish
Pages (from-to)342-351
Number of pages10
JournalMaterials Science and Engineering C
Volume77
DOIs
Publication statusPublished - 1 Aug 2017

Keywords

  • Drug delivery
  • Ibuprofen
  • Mechanical properties
  • Melanin
  • Scaffolds
  • Supercritical CO

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