@article{918900577402431683ae197ba156d901,
title = "Bioactivity, bioavailability, and gut microbiota transformations of dietary phenolic compounds: implications for COVID-19",
abstract = "The outbreak of mysterious pneumonia at the end of 2019 is associated with widespread research interest worldwide. The coronavirus disease-19 (COVID-19) targets multiple organs through inflammatory, immune, and redox mechanisms, and no effective drug for its prophylaxis or treatment has been identified until now. The use of dietary bioactive compounds, such as phenolic compounds (PC), has emerged as a putative nutritional or therapeutic adjunct approach for COVID-19. In the present study, scientific data on the mechanisms underlying the bioactivity of PC and their usefulness in COVID-19 mitigation are reviewed. In addition, antioxidant, antiviral, anti-inflammatory, and immunomodulatory effects of dietary PC are studied. Moreover, the implications of digestion on the putative benefits of dietary PC against COVID-19 are presented by addressing the bioavailability and biotransformation of PC by the gut microbiota. Lastly, safety issues and possible drug interactions of PC and their implications in COVID-19 therapeutics are discussed.",
keywords = "Coronavirus, Curcumin, Immune system, Inflammation, Oxidative stress, Quercetin, Resveratrol, SARS-CoV-2",
author = "Augusti, {Paula R.} and Conterato, {Greicy M.M.} and Denardin, {Cristiane C.} and Prazeres, {In{\^e}s D.} and Serra, {Ana Teresa} and Bronze, {Maria R.} and Tatiana Emanuelli",
note = "Funding Information: P.R.A. acknowledges CNPq (Brazilian National Scientific and Technological Development Council) for the postdoctoral scholarship [grant number 205295/2018-5 ] that made this Brazil and Portugal partnership possible. T.E. is a fellowship from the National Council for Scientific and Technological Development (CNPq) [grant number 303654/2017-1 ]. A.T.S. acknowledges Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia/Minist{\'e}rio da Educa{\c c}{\~a}o e Ci{\^e}ncia for the Individual Grant CEECIND/04801/2017. iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, a program financially supported by Funda{\c c}{\~a}o para a Ci{\^e}ncia e Tecnologia/Minist{\'e}rio da Ci{\^e}ncia, Tecnologia e Ensino Superior, through national funds is acknowledged. Funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC), is also gratefully acknowledged. Authors thank to the nutritionist Allana V. Brasil for her kind assistance in drawing figure 3 and graphical abstract. Publisher Copyright: {\textcopyright} 2021",
year = "2021",
month = nov,
doi = "10.1016/j.jnutbio.2021.108787",
language = "English",
volume = "97",
journal = "Journal of Nutritional Biochemistry",
issn = "0955-2863",
publisher = "Elsevier Science B.V., Amsterdam.",
}
