Bioactive transparent films based on polysaccharides and cholinium carboxylate ionic liquids

Liliana C. Tomé, Nuno H C S Silva, Hugo R. Soares, Ana S. Coroadinha, Patrizia Sadocco, Isabel Maria Marrucho Ferreira, Carmen S R Freire

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Novel antibacterial and biocompatible transparent films based on chitosan or pullulan and two bioactive ionic liquids (ILs), cholinium hexanoate and cholinium citrate, were prepared. These ILs were selected based on their MIC values against several microbial strains, film-forming ability when blended with the polysaccharides and biocompatibility against designated human cell lines. The films were obtained through simple casting of polysaccharide aqueous solutions containing different amounts of the ILs (20 and 40 wt% with respect to the amount of polysaccharide). The physical properties of the films were investigated using transmittance measurements, thermal analysis, mechanical testing and antibacterial assays. In general, the addition of both ILs does not affect the optical transparency (up to 80% transmittance within 400-700 nm) of the films but decreased their stiffness (acting as plasticizers) and thermal stability. All chitosan-based films showed antibacterial activity against S. aureus and K. pneumoniae but for pullulan only those with cholinium citrate were bioactive.

Original languageEnglish
Pages (from-to)4291-4299
Number of pages9
JournalGreen Chemistry
Volume17
Issue number8
DOIs
Publication statusPublished - 1 Aug 2015

Fingerprint Dive into the research topics of 'Bioactive transparent films based on polysaccharides and cholinium carboxylate ionic liquids'. Together they form a unique fingerprint.

  • Cite this