Bioactive Glass Modified with Zirconium Incorporation for Dental Implant Applications: Fabrication, Structural, Electrical, and Biological Analysis

Imen Hammami, Sílvia Rodrigues Gavinho, Ana Sofia Pádua, Isabel Sá-Nogueira, Jorge Carvalho Silva, João Paulo Borges, Manuel Almeida Valente, Manuel Pedro Fernandes Graça

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
5 Downloads (Pure)

Abstract

Implantology is crucial for restoring aesthetics and masticatory function in oral rehabilitation. Despite its advantages, certain issues, such as bacterial infection, may still arise that hinder osseointegration and result in implant rejection. This work aims to address these challenges by developing a biomaterial for dental implant coating based on 45S5 Bioglass® modified by zirconium insertion. The structural characterization of the glasses, by XRD, showed that the introduction of zirconium in the Bioglass network at a concentration higher than 2 mol% promotes phase separation, with crystal phase formation. Impedance spectroscopy was used, in the frequency range of 102–106 Hz and the temperature range of 200–400 K, to investigate the electrical properties of these Bioglasses, due to their ability to store electrical charges and therefore enhance the osseointegration capacity. The electrical study showed that the presence of crystal phases, in the glass ceramic with 8 mol% of zirconium, led to a significant increase in conductivity. In terms of biological properties, the Bioglasses exhibited an antibacterial effect against Gram-positive and Gram-negative bacteria and did not show cytotoxicity for the Saos-2 cell line at extract concentrations up to 25 mg/mL. Furthermore, the results of the bioactivity test revealed that within 24 h, a CaP-rich layer began to form on the surface of all the samples. According to our results, the incorporation of 2 mol% of ZrO2 into the Bioglass significantly improves its potential as a coating material for dental implants, enhancing both its antibacterial and osteointegration properties.
Original languageEnglish
Article number10571
Number of pages17
JournalInternational Journal of Molecular Sciences
Volume24
Issue number13
DOIs
Publication statusPublished - 24 Jun 2023

Keywords

  • antibacterial properties
  • bioactivity
  • Bioglass
  • dielectric properties
  • implant coating
  • osseointegration
  • zirconium

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