TY - JOUR
T1 - Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens
AU - Valente, Cláudia
AU - Pedro, Madalena
AU - Duarte, Aida
AU - Nascimento Maria, Maria São José
AU - Abreu, Pedro Macedo de
AU - Ferreira, Maria José U.
PY - 2004/5
Y1 - 2004/5
N2 - A new jatrophane diterpene, pubescenol (1), known ent-abietane lactones, helioscopinolide A (2) and B (3), and taraxerone, 24-methylenecycloartanol, and vanillin have been isolated from Euphorbia pubescens. Diterpenes 1-3 and previously described pubescene D (4) were shown to be moderate inhibitors of the growth of MCF-7, NCI-H460, and SF-268 human tumor cell lines, whereas compounds 2 and 3 also exhibited significant antibacterial activity against Staphylococcus aureus.
AB - A new jatrophane diterpene, pubescenol (1), known ent-abietane lactones, helioscopinolide A (2) and B (3), and taraxerone, 24-methylenecycloartanol, and vanillin have been isolated from Euphorbia pubescens. Diterpenes 1-3 and previously described pubescene D (4) were shown to be moderate inhibitors of the growth of MCF-7, NCI-H460, and SF-268 human tumor cell lines, whereas compounds 2 and 3 also exhibited significant antibacterial activity against Staphylococcus aureus.
KW - Hydrocarbons
KW - Bacteria
KW - Carbon
KW - Cells
KW - Antibacterial activity
UR - http://www.scopus.com/inward/record.url?scp=2642546475&partnerID=8YFLogxK
U2 - 10.1021/np0400048
DO - 10.1021/np0400048
M3 - Article
C2 - 15165162
SN - 0163-3864
VL - 67
SP - 902
EP - 904
JO - Journal Of Natural Products
JF - Journal Of Natural Products
IS - 5
ER -