Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens

Cláudia Valente, Madalena Pedro, Aida Duarte, Maria São José Nascimento Maria, Pedro Macedo de Abreu, Maria José U. Ferreira

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

A new jatrophane diterpene, pubescenol (1), known ent-abietane lactones, helioscopinolide A (2) and B (3), and taraxerone, 24-methylenecycloartanol, and vanillin have been isolated from Euphorbia pubescens. Diterpenes 1-3 and previously described pubescene D (4) were shown to be moderate inhibitors of the growth of MCF-7, NCI-H460, and SF-268 human tumor cell lines, whereas compounds 2 and 3 also exhibited significant antibacterial activity against Staphylococcus aureus.

Original languageEnglish
Pages (from-to)902-904
Number of pages3
JournalJournal Of Natural Products
Volume67
Issue number5
DOIs
Publication statusPublished - May 2004

Keywords

  • Hydrocarbons
  • Bacteria
  • Carbon
  • Cells
  • Antibacterial activity

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