Bioaccumulation and ecotoxicological responses of juvenile white seabream (Diplodus sargus) exposed to triclosan, warming and acidification

Ana Luísa Maulvault, Carolina Camacho, Vera Barbosa, Ricardo Alves, Patrícia Anacleto, Sara C. Cunha, José O. Fernandes, Pedro Pousão-Ferreira, José Ricardo Paula, Rui Rosa, Mário Diniz, António Marques

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Triclosan (TCS) is a synthetic microbial compound widely used in the formulation of various personal care products. Its frequent detection in marine ecosystems, along with its physical and chemical properties, suggest that TCS can be highly persistent, being easily bioaccumulated by biota and, therefore, eliciting various toxicological responses. Yet, TCS's mechanisms of bioaccumulation and toxicity still deserve further research, particularly focusing on the interactive effects with climate change-related stressors (e.g. warming and acidification), as both TCS chemical behaviour and marine species metabolism/physiology can be strongly influenced by the surrounding abiotic conditions. Hence, the aim of this study was to assess TCS bioaccumulation and ecotoxicological effects (i.e. animal fitness indexes, antioxidant activity, protein chaperoning and degradation, neurotoxicity and endocrine disruption) in three tissues (i.e. brain, liver and muscle) of juvenile Diplodus sargus exposed to the interactive effects of TCS dietary exposure (15.9 μg kg−1 dw), seawater warming (ΔTºC = +5 °C) and acidification (ΔpCO2 ∼ +1000 μatm, equivalent to ΔpH = −0.4 units). Muscle was the primary organ of TCS bioaccumulation, and climate change stressors, particularly warming, significantly reduced TCS bioaccumulation in all fish tissues. Furthermore, the negative ecotoxicological responses elicited by TCS were significantly altered by the co-exposure to acidification and/or warming, through either the enhancement (e.g. vitellogenin content) or counteraction/inhibition (e.g. heat shock proteins HSP70/HSC70 content) of molecular biomarker responses, with the combination of TCS plus acidification resulting in more severe alterations. Thus, the distinct patterns of TCS tissue bioaccumulation and ecotoxicological responses induced by the different scenarios emphasized the need to further understand the interactive effects between pollutants and abiotic conditions, as such knowledge enables a better estimation and mitigation of the toxicological impacts of climate change in marine ecosystems. Warming and acidification decreased TCS tissue bioaccumulation. TCS ecotoxicological effects were influenced by temperature and pCO2 levels.

Original languageEnglish
Pages (from-to)427-442
Number of pages16
JournalEnvironmental Pollution
Volume245
DOIs
Publication statusPublished - 1 Feb 2019

Fingerprint

Triclosan
Sea Bream
Bioaccumulation
Acidification
Climate change
Tissue
Aquatic ecosystems
Muscle
Climate Change
Proteins
Physiology
Biomarkers
Antioxidants
Seawater
Metabolism
Liver
Toxicology
Fish
Chemical properties
Ecosystem

Keywords

  • Acidification
  • Bioaccumulation
  • Multi-biomarkers responses
  • Triclosan
  • Warming

Cite this

Maulvault, Ana Luísa ; Camacho, Carolina ; Barbosa, Vera ; Alves, Ricardo ; Anacleto, Patrícia ; Cunha, Sara C. ; Fernandes, José O. ; Pousão-Ferreira, Pedro ; Paula, José Ricardo ; Rosa, Rui ; Diniz, Mário ; Marques, António. / Bioaccumulation and ecotoxicological responses of juvenile white seabream (Diplodus sargus) exposed to triclosan, warming and acidification. In: Environmental Pollution. 2019 ; Vol. 245. pp. 427-442.
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abstract = "Triclosan (TCS) is a synthetic microbial compound widely used in the formulation of various personal care products. Its frequent detection in marine ecosystems, along with its physical and chemical properties, suggest that TCS can be highly persistent, being easily bioaccumulated by biota and, therefore, eliciting various toxicological responses. Yet, TCS's mechanisms of bioaccumulation and toxicity still deserve further research, particularly focusing on the interactive effects with climate change-related stressors (e.g. warming and acidification), as both TCS chemical behaviour and marine species metabolism/physiology can be strongly influenced by the surrounding abiotic conditions. Hence, the aim of this study was to assess TCS bioaccumulation and ecotoxicological effects (i.e. animal fitness indexes, antioxidant activity, protein chaperoning and degradation, neurotoxicity and endocrine disruption) in three tissues (i.e. brain, liver and muscle) of juvenile Diplodus sargus exposed to the interactive effects of TCS dietary exposure (15.9 μg kg−1 dw), seawater warming (ΔTºC = +5 °C) and acidification (ΔpCO2 ∼ +1000 μatm, equivalent to ΔpH = −0.4 units). Muscle was the primary organ of TCS bioaccumulation, and climate change stressors, particularly warming, significantly reduced TCS bioaccumulation in all fish tissues. Furthermore, the negative ecotoxicological responses elicited by TCS were significantly altered by the co-exposure to acidification and/or warming, through either the enhancement (e.g. vitellogenin content) or counteraction/inhibition (e.g. heat shock proteins HSP70/HSC70 content) of molecular biomarker responses, with the combination of TCS plus acidification resulting in more severe alterations. Thus, the distinct patterns of TCS tissue bioaccumulation and ecotoxicological responses induced by the different scenarios emphasized the need to further understand the interactive effects between pollutants and abiotic conditions, as such knowledge enables a better estimation and mitigation of the toxicological impacts of climate change in marine ecosystems. Warming and acidification decreased TCS tissue bioaccumulation. TCS ecotoxicological effects were influenced by temperature and pCO2 levels.",
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author = "Maulvault, {Ana Lu{\'i}sa} and Carolina Camacho and Vera Barbosa and Ricardo Alves and Patr{\'i}cia Anacleto and Cunha, {Sara C.} and Fernandes, {Jos{\'e} O.} and Pedro Pous{\~a}o-Ferreira and Paula, {Jos{\'e} Ricardo} and Rui Rosa and M{\'a}rio Diniz and Ant{\'o}nio Marques",
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Maulvault, AL, Camacho, C, Barbosa, V, Alves, R, Anacleto, P, Cunha, SC, Fernandes, JO, Pousão-Ferreira, P, Paula, JR, Rosa, R, Diniz, M & Marques, A 2019, 'Bioaccumulation and ecotoxicological responses of juvenile white seabream (Diplodus sargus) exposed to triclosan, warming and acidification', Environmental Pollution, vol. 245, pp. 427-442. https://doi.org/10.1016/j.envpol.2018.11.020

Bioaccumulation and ecotoxicological responses of juvenile white seabream (Diplodus sargus) exposed to triclosan, warming and acidification. / Maulvault, Ana Luísa; Camacho, Carolina; Barbosa, Vera; Alves, Ricardo; Anacleto, Patrícia; Cunha, Sara C.; Fernandes, José O.; Pousão-Ferreira, Pedro; Paula, José Ricardo; Rosa, Rui; Diniz, Mário; Marques, António.

In: Environmental Pollution, Vol. 245, 01.02.2019, p. 427-442.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bioaccumulation and ecotoxicological responses of juvenile white seabream (Diplodus sargus) exposed to triclosan, warming and acidification

AU - Maulvault, Ana Luísa

AU - Camacho, Carolina

AU - Barbosa, Vera

AU - Alves, Ricardo

AU - Anacleto, Patrícia

AU - Cunha, Sara C.

AU - Fernandes, José O.

AU - Pousão-Ferreira, Pedro

AU - Paula, José Ricardo

AU - Rosa, Rui

AU - Diniz, Mário

AU - Marques, António

N1 - info:eu-repo/grantAgreement/EC/FP7/311820/EU# info:eu-repo/grantAgreement/FCT/5876/147321/PT# info:eu-repo/grantAgreement/FCT/5876/147258/PT# The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under the ECsafeSEAFOOD project (grant agreement no 311820). The present study was also funded by The Portuguese Foundation for Science and Technology (FCT), through the: i) strategic project UID/MAR/04292/2013 granted to MARE, ii) FCT/MCTES project UID/Multi/04378/2013 co-financed by the ERDF under the PT2020 Partnership Agreement POCI-01-0145-FEDER-007728 granted to the Applied Molecular Biosciences Unit-UCIBIO; iii) the contracts of SCC (IF/01616/2015), AM (IF/00157/2014) and RR (IF/01373/2013) in the framework of the IF program; and iv) the PhD Grant of ALM (SFRH/BD/103569/2014) and Post-PhD Grant of PA (SFRH/BPD/100728/2014).

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Triclosan (TCS) is a synthetic microbial compound widely used in the formulation of various personal care products. Its frequent detection in marine ecosystems, along with its physical and chemical properties, suggest that TCS can be highly persistent, being easily bioaccumulated by biota and, therefore, eliciting various toxicological responses. Yet, TCS's mechanisms of bioaccumulation and toxicity still deserve further research, particularly focusing on the interactive effects with climate change-related stressors (e.g. warming and acidification), as both TCS chemical behaviour and marine species metabolism/physiology can be strongly influenced by the surrounding abiotic conditions. Hence, the aim of this study was to assess TCS bioaccumulation and ecotoxicological effects (i.e. animal fitness indexes, antioxidant activity, protein chaperoning and degradation, neurotoxicity and endocrine disruption) in three tissues (i.e. brain, liver and muscle) of juvenile Diplodus sargus exposed to the interactive effects of TCS dietary exposure (15.9 μg kg−1 dw), seawater warming (ΔTºC = +5 °C) and acidification (ΔpCO2 ∼ +1000 μatm, equivalent to ΔpH = −0.4 units). Muscle was the primary organ of TCS bioaccumulation, and climate change stressors, particularly warming, significantly reduced TCS bioaccumulation in all fish tissues. Furthermore, the negative ecotoxicological responses elicited by TCS were significantly altered by the co-exposure to acidification and/or warming, through either the enhancement (e.g. vitellogenin content) or counteraction/inhibition (e.g. heat shock proteins HSP70/HSC70 content) of molecular biomarker responses, with the combination of TCS plus acidification resulting in more severe alterations. Thus, the distinct patterns of TCS tissue bioaccumulation and ecotoxicological responses induced by the different scenarios emphasized the need to further understand the interactive effects between pollutants and abiotic conditions, as such knowledge enables a better estimation and mitigation of the toxicological impacts of climate change in marine ecosystems. Warming and acidification decreased TCS tissue bioaccumulation. TCS ecotoxicological effects were influenced by temperature and pCO2 levels.

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KW - Bioaccumulation

KW - Multi-biomarkers responses

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KW - Warming

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